National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases/Obesity and Diabetes Clinical Research Section, 4212 North 16th St, Room 541, Phoenix, AZ 85016.
Psychosom Med. 2014 Jan;76(1):74-9. doi: 10.1097/PSY.0000000000000018. Epub 2013 Dec 23.
Ghrelin, a peptide hormone secreted mainly by the stomach, increases appetite and food intake. Surprisingly, ghrelin levels are lower in obese individuals with binge eating disorder (BED) than in obese non-BED individuals. Acute psychological stress has been shown to raise ghrelin levels in animals and humans. Our aim was to assess ghrelin levels after a cold pressor test (CPT) in women with BED. We also examined the relationship between the cortisol stress response and changes in ghrelin levels.
Twenty-one obese (mean [standard deviation] body mass index = 34.9 [5.8] kg/m(2)) women (10 non-BED, 11 BED) underwent the CPT, hand submerged in ice water for 2 minutes. Blood samples were drawn for 70 minutes and assayed for ghrelin and cortisol.
There were no differences between the groups in ghrelin levels at baseline (-10 minutes). Ghrelin rose significantly after the CPT (F = 2.4, p = .024) peaking at 19 minutes before declining (F = 17.9, p < .001), but there were no differences between the BED and non-BED groups. Area under the curve for ghrelin was not related to ratings of pain, stress, hunger, or desire to eat after CPT. In addition, there were no observed relationships between the area under the curves for ghrelin or cortisol after stress.
Although there were no differences between BED groups, there was a significant rise in ghrelin in obese humans after a stressor, consistent with other recent reports suggesting a stress-related role for ghrelin.
胃分泌的肽类激素 ghrelin 可增加食欲和食物摄入量。令人惊讶的是，与非暴食障碍（BED）肥胖个体相比，暴食障碍（BED）肥胖个体的 ghrelin 水平较低。急性心理应激已被证明可提高动物和人类的 ghrelin 水平。我们的目的是评估 BED 女性在冷加压试验（CPT）后 ghrelin 水平。我们还研究了皮质醇应激反应与 ghrelin 水平变化之间的关系。
21 名肥胖（平均[标准差]体重指数=34.9[5.8]kg/m2）女性（10 名非 BED，11 名 BED）接受 CPT，手浸入冰水 2 分钟。在 70 分钟内抽取血液样本并测定 ghrelin 和皮质醇。
两组在基线（-10 分钟）时 ghrelin 水平无差异。CPT 后 ghrelin 显著升高（F=2.4，p=0.024），19 分钟时达到峰值，然后下降（F=17.9，p<0.001），但 BED 和非 BED 组之间无差异。CPT 后 ghrelin 的曲线下面积与疼痛、应激、饥饿或进食欲望评分无关。此外，应激后 ghrelin 或皮质醇的曲线下面积之间未见相关关系。
尽管 BED 组之间无差异，但肥胖者在应激后 ghrelin 水平显著升高，与其他最近的报告一致，提示 ghrelin 与应激有关。
