Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Public Health. 2022 Nov 14;10:1015861. doi: 10.3389/fpubh.2022.1015861. eCollection 2022.
Leukemia caused by occupational risk is a problem that needs more attention and remains to be solved urgently, especially for acute lymphoid leukemia (ALL), acute myeloid leukemia (AML), and chronic lymphoid leukemia (CLL). However, there is a paucity of literature on this issue. We aimed to assess the global burden and trends of leukemia attributable to occupational risk from 1990 to 2019.
This observational trend study was based on the Global Burden of Disease (GBD) 2019 database, the global deaths, and disability-adjusted life years (DALYs), which were calculated to quantify the changing trend of leukemia attributable to occupational risk, were analyzed by age, year, geographical location, and socio-demographic index (SDI), and the corresponding estimated annual percentage change (EAPC) values were calculated.
Global age-standardized DALYs and death rates of leukemia attributable to occupational risk presented significantly decline trends with EAPC [-0.38% (95% CI: -0.58 to -0.18%) for DALYs and -0.30% (95% CI: -0.45 to -0.146%) for death]. However, it was significantly increased in people aged 65-69 years [0.42% (95% CI: 0.30-0.55%) for DALYs and 0.38% (95% CI: 0.26-0.51%) for death]. At the same time, the age-standardized DALYs and death rates of ALL, AML, and CLL were presented a significantly increased trend with EAPCs [0.78% (95% CI: 0.65-0.91%), 0.87% (95% CI: 0.81-0.93%), and 0.66% (95% CI: 0.51-0.81%) for DALYs, respectively, and 0.75% (95% CI: 0.68-0.82%), 0.96% (95% CI: 0.91-1.01%), and 0.55% (95% CI: 0.43-0.68%) for death], respectively. The ALL, AML, and CLL were shown an upward trend in almost all age groups.
We observed a substantial reduction in leukemia due to occupational risks between 1990 and 2019. However, the people aged 65-69 years and burdens of ALL, AML, and CLL had a significantly increased trend in almost all age groups. Thus, there remains an urgent need to accelerate efforts to reduce leukemia attributable to occupational risk-related death burden in this population and specific causes.
职业风险导致的白血病是一个需要更多关注并亟待解决的问题，尤其是急性淋巴细胞白血病（ALL）、急性髓细胞白血病（AML）和慢性淋巴细胞白血病（CLL）。然而，关于这个问题的文献却很少。我们旨在评估 1990 年至 2019 年职业风险导致的白血病的全球负担和趋势。
本观察性趋势研究基于全球疾病负担（GBD）2019 数据库，计算全球死亡人数和伤残调整生命年（DALY），以量化职业风险导致的白血病的变化趋势，按年龄、年份、地理位置和社会人口指数（SDI）进行分析，并计算相应的估计年平均变化率（EAPC）值。
职业风险导致的白血病的全球年龄标准化 DALY 和死亡率呈现显著下降趋势，EAPC 值分别为-0.38%（95%CI：-0.58 至-0.18%）和-0.30%（95%CI：-0.45 至-0.146%）。然而，65-69 岁人群的 DALY 和死亡率却显著增加，分别为 0.42%（95%CI：0.30-0.55%）和 0.38%（95%CI：0.26-0.51%）。同时，ALL、AML 和 CLL 的年龄标准化 DALY 和死亡率呈现出显著上升趋势，EAPC 值分别为 0.78%（95%CI：0.65-0.91%）、0.87%（95%CI：0.81-0.93%）和 0.66%（95%CI：0.51-0.81%），0.75%（95%CI：0.68-0.82%）、0.96%（95%CI：0.91-1.01%）和 0.55%（95%CI：0.43-0.68%）。ALL、AML 和 CLL 的年龄标准化 DALY 和死亡率在几乎所有年龄组都呈现上升趋势。
我们观察到，1990 年至 2019 年间，职业风险导致的白血病的负担显著降低。然而，65-69 岁人群以及 ALL、AML 和 CLL 的负担在几乎所有年龄组都呈现出显著上升趋势。因此，迫切需要加快努力，减少这一年龄段和特定病因导致的职业风险相关白血病死亡负担。
