Department of Molecular Biotechnology, School of Life & Environmental Sciences, Konkuk University, Seoul 143701, South Korea.
Appl Biochem Biotechnol. 2012 Nov;168(6):1694-717. doi: 10.1007/s12010-012-9890-6. Epub 2012 Sep 16.
Glucosinolates (GSL) and their derivatives are well known for the characteristic roles they play in plant defense as signaling molecules and as bioactive compounds for human health. More than 130 GSLs have been reported so far, and most of them belong to the Brassicaceae family. Several enzymes and transcription factors involved in the GSL biosynthesis have been studied in the model plant, Arabidopsis, and in a few other Brassica crop species. Recent studies in GSL research have defined the regulation, distribution, and degradation of GSL biosynthetic pathways; however, the underlying mechanism behind transportation of GSLs in plants is still largely unknown. This review highlights the recent advances in the metabolic engineering of GSLs in plants and discusses their potential applications.
硫代葡萄糖苷（GSL）及其衍生物是植物防御中信号分子和生物活性化合物的特征角色，这一点众所周知。迄今为止，已经报道了超过 130 种 GSL，其中大多数属于十字花科植物。在模式植物拟南芥和少数其他芸薹属作物物种中，已经研究了几种参与 GSL 生物合成的酶和转录因子。最近的 GSL 研究定义了 GSL 生物合成途径的调控、分布和降解；然而，植物中 GSL 运输的潜在机制在很大程度上仍然未知。本文综述了植物中 GSL 代谢工程的最新进展，并讨论了它们的潜在应用。
