Kaneria Mahesh S, Naik S R, Kohli R K
K. M. Kundanani College of Pharmacy, Colaba, Mumbai, 400 005, India.
Indian J Exp Biol. 2007 Mar;45(3):278-84.
Anti-inflammatory, antiarthritic and analgesic effect of a herbal product (DRF/AY/4012) was evaluated in animal models. Herbal product treatment induced a dose dependent anti-inflammatory activity in acute inflammatory models (carrageenin and egg-albumin induced rat hind paw edema). It also elicited promising anti-inflammatory activity in chronic inflammatory models (cotton pellet granuloma and Freund's adjuvant induced polyarthritis in rats). Further, the product inhibited the increased level of serum lysosomal enzyme activity viz. serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase and the lipid peroxidation in liver. In Freund's adjuvant induced polyarthritis, herbal product reduced the increased level of hydroxy proline, hexosamine and total protein content in edematous tissue. The product also exhibited mild to moderate analgesic activity in acetic acid induced writhing in mice. The LD50 value of the herbal product was more than 16 gm/kg by oral route in mice. The product has distinct advantages over the existing agents and deserves further developmental studies.
在动物模型中评估了一种草药产品（DRF/AY/4012）的抗炎、抗关节炎和镇痛作用。在急性炎症模型（角叉菜胶和蛋清诱导的大鼠后爪水肿）中，草药产品治疗呈现出剂量依赖性抗炎活性。它在慢性炎症模型（棉球肉芽肿和弗氏佐剂诱导的大鼠多关节炎）中也引发了有前景的抗炎活性。此外，该产品抑制了血清溶酶体酶活性水平的升高，即血清谷氨酸草酰乙酸转氨酶、血清谷氨酸丙酮酸转氨酶、碱性磷酸酶以及肝脏中的脂质过氧化。在弗氏佐剂诱导的多关节炎中，草药产品降低了水肿组织中羟脯氨酸、己糖胺和总蛋白含量的升高水平。该产品在醋酸诱导的小鼠扭体实验中也表现出轻度至中度的镇痛活性。该草药产品经口给药在小鼠中的半数致死量值大于16克/千克。该产品相对于现有药物具有明显优势，值得进一步开展研发研究。
