Leproult Rachel, Deliens Gaétane, Gilson Médhi, Peigneux Philippe
Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium.
CO3-Consciousness, Cognition & Computation Group, Center for Research in Cognition and Neurosciences and the ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Sleep. 2015 May 1;38(5):707-15. doi: 10.5665/sleep.4660.
A link between sleep loss and increased risk for the development of diabetes is now well recognized. The current study investigates whether sleep extension under real-life conditions is a feasible intervention with a beneficial impact on glucose metabolism in healthy adults who are chronically sleep restricted.
Intervention study.
Sixteen healthy non-obese volunteers (25 [23, 27.8] years old, 3 men).
Two weeks of habitual time in bed followed by 6 weeks during which participants were instructed to increase their time in bed by one hour per day.
Continuous actigraphy monitoring and daily sleep logs during the entire study. Glucose and insulin were assayed on a single morning blood sample at the end of habitual time in bed and at the end of sleep extension. Home polysomnography was performed during one weekday of habitual time in bed and after 40 days of sleep extension. Sleep time during weekdays increased (mean actigraphic data: +44 ± 34 minutes, P < 0.0001; polysomnographic data: +49 ± 68 minutes, P = 0.014), without any significant change during weekends. Changes from habitual time in bed to the end of the intervention in total sleep time correlated with changes in glucose (r = +0.53, P = 0.041) and insulin levels (r = -0.60, P = 0.025), as well as with indices of insulin sensitivity (r = +0.76, P = 0.002).
In healthy adults who are chronically sleep restricted, a simple low cost intervention such as sleep extension is feasible and is associated with improvements in fasting insulin sensitivity.
睡眠不足与糖尿病发病风险增加之间的联系现已得到充分认识。本研究调查了在现实生活条件下延长睡眠时间对于长期睡眠受限的健康成年人的葡萄糖代谢是否是一种可行的干预措施且具有有益影响。
干预性研究。
16名健康非肥胖志愿者（年龄25[23,27.8]岁，3名男性）。
两周的习惯卧床时间，随后6周，在此期间指导参与者每天将卧床时间增加1小时。
在整个研究期间进行连续的活动记录仪监测和每日睡眠日志记录。在习惯卧床时间结束时和延长睡眠结束时，采集单次早晨血样检测葡萄糖和胰岛素水平。在习惯卧床时间的一个工作日以及延长睡眠40天后进行家庭多导睡眠图检查。工作日的睡眠时间增加（平均活动记录仪数据：+44±34分钟，P<0.0001；多导睡眠图数据：+49±68分钟，P = 0.014），周末无显著变化。从习惯卧床时间到干预结束时总睡眠时间的变化与葡萄糖（r = +0.53，P = 0.041）、胰岛素水平变化（r = -0.60，P = 0.025）以及胰岛素敏感性指标（r = +0.76，P = 0.002）相关。
对于长期睡眠受限的健康成年人，像延长睡眠时间这样简单且低成本的干预措施是可行的，并且与空腹胰岛素敏感性的改善相关联。
