Saedi Nazanin, Metelitsa Andrei, Petrell Kathleen, Arndt Kenneth A, Dover Jeffrey S
Arch Dermatol. 2012 Dec;148(12):1360-3. doi: 10.1001/archdermatol.2012.2894.
OBJECTIVE To study a picosecond 755-nm alexandrite laser for the removal of tattoos to confirm the efficacy of this therapy, focusing on the effect of therapy on the target lesion as well as the surrounding tissues and quantifying the number of necessary treatments. DESIGN Fifteen patients with tattoos were enrolled. Treatments were scheduled approximately 6 ± 2 weeks apart. Standard photographs using 2-dimensional imaging were taken at baseline, before each treatment, and 1 month and 3 months after the last treatment. SETTING Dermatology clinic at SkinCare Physicians in Chestnut Hill, Massachusetts. PATIENTS Fifteen patients with darkly pigmented tattoos. MAIN OUTCOME MEASURES Treatment efficacy was assessed by the level of tattoo clearance in standard photographs. These photographs were assessed by a blinded physician evaluator and based on a 4-point scale. Efficacy was also assessed based on physician and patient satisfaction measured on a 4-point scale. RESULTS Twelve of 15 patients with tattoos (80%) completed the study. All 12 patients obtained greater than 75% clearance. Nine patients (75%) obtained greater than 75% clearance after having 2 to 4 treatments. The average number of treatment sessions needed to obtain this level of clearance was 4.25. All 12 patients (100%) were satisfied or extremely satisfied with the treatment. Adverse effects included pain, swelling, and blistering. Pain resolved immediately after therapy, while the swelling and blistering resolved within 1 week. Hypopigmentation and hyperpigmentation were reported at the 3-month follow-up. CONCLUSION The picosecond 755-nm alexandrite laser is a safe and very effective procedure for removing tattoo pigment.
目的 研究皮秒755纳米翠绿宝石激光用于去除纹身，以确认该疗法的疗效，重点关注治疗对目标皮损以及周围组织的影响，并量化所需治疗的次数。设计 招募了15名纹身患者。治疗安排间隔约6±2周。在基线、每次治疗前、最后一次治疗后1个月和3个月时，使用二维成像拍摄标准照片。地点 马萨诸塞州栗树山皮肤护理医师诊所的皮肤科。患者 15名深色纹身患者。主要观察指标 通过标准照片中的纹身清除程度评估治疗效果。这些照片由一名不知情的医生评估员根据4分制进行评估。还根据医生和患者的满意度（4分制）评估疗效。结果 15名纹身患者中有12名（80%）完成了研究。所有12名患者的清除率均超过75%。9名患者（75%）在接受2至4次治疗后清除率超过75%。达到该清除水平所需的平均治疗次数为4.25次。所有12名患者（100%）对治疗感到满意或极其满意。不良反应包括疼痛、肿胀和水疱。治疗后疼痛立即缓解，肿胀和水疱在1周内消退。在3个月随访时报告有色素减退和色素沉着。结论 皮秒755纳米翠绿宝石激光是一种安全且非常有效的去除纹身色素的方法。
