吡咯-咪唑聚酰胺能区分双链 DNA 和 RNA。
Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.
机构信息
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, 91125, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jan 2;52(1):415-8. doi: 10.1002/anie.201205775. Epub 2012 Sep 14.
Abstract
Groove specificity: pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA. However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.
摘要
沟道特异性
吡咯-咪唑聚酰胺以其与 DNA 小沟的特异性相互作用而闻名。然而，聚酰胺对双链 RNA 没有类似的结合作用，并且提出了一个结构原理，用于解释小沟结合配体对核酸双链的分子水平区分。
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