先天性克氏锥虫在非流行地区的传播：西班牙巴塞罗那一家三级保健医院筛查计划的评估。
Congenital transmission of Trypanosoma cruzi in non-endemic areas: evaluation of a screening program in a tertiary care hospital in Barcelona, Spain.
机构信息
Department of Preventive Medicine and Epidemiology, Vall d'Hebron University Hospital, Barcelona, Spain.
出版信息
Am J Trop Med Hyg. 2012 Nov;87(5):832-6. doi: 10.4269/ajtmh.2012.12-0152. Epub 2012 Sep 17.
Abstract
The impact of Chagas disease is no longer restricted to endemic areas. The aim of this study is to evaluate a 2-year period of a vertical transmission screening program of Trypanosoma cruzi infection in a tertiary care hospital in Barcelona (Spain). Two enzyme-linked immunosorbent assays (recombinant and crude antigen) were performed in parallel to pregnant women at risk of T. cruzi infection. Discordant results were confirmed by a third diagnostic test. In the case of a positive result, the newborn was tested at birth and after 8 months of life. A total of 1,473 women met the inclusion criteria for the screening program with a resulting seroprevalence for T. cruzi of 3.5% (2.2-5.2% 95% confidence interval [95% CI]). One case of congenital infection was identified. Screening programs for vertically transmitted T. cruzi acute infection are beneficial in non-endemic areas for early detection and treatment of acute infection.
摘要
克氏锥虫感染的垂直传播筛查项目在非流行地区的 2 年评估
本研究旨在评估在巴塞罗那（西班牙）的一家三级保健医院开展的为期 2 年的克氏锥虫感染垂直传播筛查项目。对有感染克氏锥虫风险的孕妇并行应用两种酶联免疫吸附试验（重组抗原和粗制抗原）。对检测结果不一致者进行第三种诊断性检测以确认结果。如果检测结果阳性，新生儿在出生时及 8 月龄时再次进行检测。共有 1473 名符合筛查项目纳入标准的妇女，克氏锥虫血清阳性率为 3.5%（95%置信区间[95%CI]：2.2%-5.2%）。发现 1 例先天性感染。在非流行地区开展针对垂直传播的克氏锥虫急性感染的筛查项目有利于早期发现和治疗急性感染。
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