Department of Nutrition Sciences, University of Alabama at Birmingham, 427 Webb Building, 1675 University Blvd, Birmingham, AL 35294-3360, USA.
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):382-8. doi: 10.1093/gerona/gls188. Epub 2012 Sep 17.
The purpose of this investigation was to examine the associations between circulating markers of inflammation and arterial elasticity in healthy older women. Participants were 50 women older than 60 years of age, body mass index 27 ± 4, and physically untrained. Large artery elasticity, small artery elasticity, systemic vascular resistance, total vascular impedance, estimated cardiac output, and estimated cardiac index were determined using pulse contour analysis. Serum concentrations of tumor necrosis factor-α, C-reactive protein (CRP), and interleukin 6 were assessed. Results from Pearson's correlation revealed that tumor necrosis factor-α was inversely associated with large artery elasticity (-.426, p < .01) and estimated cardiac index (-.324, p < .05) and positively associated with systemic vascular resistance (.386, p < .01) and total vascular impedance (.416, p < .01). Additionally, C-reactive protein was inversely associated with large artery elasticity (-.308, p < .01). The overall implication was that tumor necrosis factor-α and C-reactive protein appear to be critical inflammatory cytokines associated with reductions in arterial elasticity in older women.
本研究旨在探讨健康老年女性循环炎症标志物与动脉弹性之间的关系。参与者为 50 名年龄大于 60 岁、体重指数为 27±4、未经体育训练的女性。使用脉搏轮廓分析测定大动脉弹性、小动脉弹性、全身血管阻力、总血管阻抗、估计心输出量和估计心指数。检测血清肿瘤坏死因子-α、C 反应蛋白（CRP）和白细胞介素 6 的浓度。Pearson 相关分析结果表明，肿瘤坏死因子-α与大动脉弹性呈负相关（-.426，p<.01），与估计心指数呈负相关（-.324，p<.05），与全身血管阻力呈正相关（.386，p<.01），与总血管阻抗呈正相关（.416，p<.01）。此外，C 反应蛋白与大动脉弹性呈负相关（-.308，p<.01）。总体而言，肿瘤坏死因子-α和 C 反应蛋白似乎是与老年女性动脉弹性降低相关的关键炎症细胞因子。
