State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
Bioorg Med Chem Lett. 2012 Oct 15;22(20):6377-80. doi: 10.1016/j.bmcl.2012.08.074. Epub 2012 Aug 26.
Zizimauritic acids A-C (1-3), three novel nortriterpenes with a unique A-nor-E-seco spiro-lactone ceanothane-type triterpene skeleton, together with 3 known triterpenes ceanothenic acid (4), betulinic acid (5), and ceanothic acid (6), were isolated from the roots of Ziziphus mauritiana. Compounds 1-4 showed cytotoxicities with the IC(50) values ranging from 5.05 to 11.94 μg/ml, and compounds 1 and 3 showed an inhibitory effect on the growth of Staphylococcus aureus with the IC(50) values 2.17 and 12.79 μg/ml. A plausible biosynthetic pathway of compounds 1-3 was proposed.
梓醇毛叶酸 A-C（1-3），三种新型的具有独特的 A-降-E-裂环螺内酯桉烷型三萜骨架的降三萜酸，与 3 种已知的三萜酸毛叶酸（4）、白桦脂酸（5）和桉烷酸（6）一起，从毛叶枣的根部分离得到。化合物 1-4 具有细胞毒性，IC50 值范围为 5.05-11.94 μg/ml，化合物 1 和 3 对金黄色葡萄球菌的生长具有抑制作用，IC50 值分别为 2.17 和 12.79 μg/ml。提出了化合物 1-3 的可能生物合成途径。
