Habenicht Lauren M, Webb Tracy L, Clauss Laurie A, Dow Steven W, Quimby Jessica M
Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
J Feline Med Surg. 2013 Feb;15(2):99-104. doi: 10.1177/1098612X12461007. Epub 2012 Sep 18.
Chronic kidney disease (CKD) is a common cause of illness and death in cats. The hallmark of CKD in cats is chronic tubulointerstitial nephritis, and inflammation contributes to the progression of renal fibrosis. However, at present, it is difficult to assess directly the degree of intra-renal inflammation without renal biopsy. Measurement of inflammatory cytokine levels in urine may provide a non-invasive means of assessing intra-renal inflammation. Urine cytokine levels (urine cytokine/urine creatinine ratio) were measured in 18 healthy cats and 26 cats with CKD. When urine cytokine levels in healthy and CKD cats were compared, we found significantly higher levels of IL-8 and transforming growth factor-β1 (TGF-β1) in urine of CKD cats, along with significantly lower vascular endothelial growth factor (VEGF) levels. A significant positive correlation between serum creatinine and TGF-β1 levels was found in CKD cats. Urinary cytokine measurement may, potentially, be a useful means of assessing intra-renal inflammation, fibrosis and vascular health in cats with CKD.
慢性肾脏病（CKD）是猫患病和死亡的常见原因。猫CKD的标志是慢性肾小管间质性肾炎，炎症会促使肾纤维化进展。然而，目前在不进行肾活检的情况下，很难直接评估肾内炎症程度。检测尿液中的炎性细胞因子水平可能提供一种评估肾内炎症的非侵入性方法。对18只健康猫和26只患有CKD的猫测量了尿细胞因子水平（尿细胞因子/尿肌酐比值）。比较健康猫和CKD猫的尿细胞因子水平时，我们发现CKD猫尿液中白细胞介素-8（IL-8）和转化生长因子-β1（TGF-β1）水平显著更高，而血管内皮生长因子（VEGF）水平显著更低。在CKD猫中，血清肌酐与TGF-β1水平之间存在显著正相关。检测尿细胞因子可能是评估CKD猫肾内炎症、纤维化和血管健康的一种有用方法。
