VIB Department of Structural Biology, Vrije Universiteit Brussel, Brussels, Belgium.
Trends Biochem Sci. 2012 Dec;37(12):509-16. doi: 10.1016/j.tibs.2012.08.004. Epub 2012 Sep 16.
The suggestion that the native state of many proteins is intrinsically disordered (or, as originally termed, unstructured) is now integral to our general view of protein structure and function. A little more than 10 years ago, however, such challenge to the almost dogmatic 'structure-function paradigm' was pure heresy due to the overwhelming evidence that structure determines function. A decade of steady progress turned skepticism around: this 10-year recap review outlines the situation a decade ago and the major directions of the breathtaking advance achieved by experimental and computational approaches. I show that the evidence for the generality and importance of this phenomenon is now so insurmountable that it demands the inclusion of 'unstructural' biology into mainstream biology and biochemistry textbooks.
现在，许多蛋白质的天然状态本质上是无序的（或者，最初被称为无结构的）这一观点，已经成为我们对蛋白质结构和功能的普遍看法的一部分。然而，就在 10 多年前，由于结构决定功能的压倒性证据，这种对几乎教条式的“结构-功能范式”的挑战纯粹是异端邪说。10 年来的稳步进展扭转了人们的怀疑态度：这篇 10 年回顾性综述概述了 10 年前的情况，以及实验和计算方法所取得的惊人进展的主要方向。我表明，现在这种现象的普遍性和重要性的证据是如此不可逾越，以至于它要求将“非结构”生物学纳入主流生物学和生物化学教材。
