Stepan Desdemona, Simionescu Cristiana, Stepan A, Muntean Mihaela, Voinea B
Department of Pathology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Rom J Morphol Embryol. 2012;53(3):585-9.
In this study, we analyzed the VEGF and CD105 immunoexpression in 24 cervical squamous cell carcinomas and CIN associated lesions with different degrees. For both lesions, MVD values were higher in patients who had associated risk factors. VEGF and MVD expression increased in both categories for high-grade lesions, respectively CIN III lesions compared with CIN I/II and poorly differentiated carcinomas compared with well-differentiated ones. Also, there was a statistically significant association between VEGF and MVD in poorly differentiated carcinoma and CIN III. The study indicated that analyzed markers were specific for both early and advanced stages of cervical angiogenesis. Maximum values of VEGF and MVD in CIN III designate this lesion as critical to the progression of neoplasia.
在本研究中，我们分析了24例宫颈鳞状细胞癌及不同程度的CIN相关病变中VEGF和CD105的免疫表达情况。对于这两种病变，有相关危险因素的患者其MVD值更高。在高级别病变中，VEGF和MVD表达均增加，分别为CIN III病变与CIN I/II相比，以及低分化癌与高分化癌相比。此外，在低分化癌和CIN III中，VEGF与MVD之间存在统计学上的显著关联。该研究表明，所分析的标志物对宫颈血管生成的早期和晚期阶段均具有特异性。CIN III中VEGF和MVD的最大值表明该病变对肿瘤形成的进展至关重要。
