Department of Biological Sciences, Clemson University, 132 Long Hall, Clemson, SC 29634, USA.
Oxid Med Cell Longev. 2012;2012:718491. doi: 10.1155/2012/718491. Epub 2012 Sep 6.
Aging is a complex and inevitable biological process that is associated with numerous chronically debilitating health effects. Development of effective interventions for promoting healthy aging is an active but challenging area of research. Mechanistic studies in various model organisms, noticeably two invertebrates, Caenorhabditis elegans and Drosophila melanogaster, have identified many genes and pathways as well as dietary interventions that modulate lifespan and healthspan. These studies have shed light on some of the mechanisms involved in aging processes and provide valuable guidance for developing efficacious aging interventions. Nutraceuticals made from various plants contain a significant amount of phytochemicals with diverse biological activities. Phytochemicals can modulate many signaling pathways that exert numerous health benefits, such as reducing cancer incidence and inflammation, and promoting healthy aging. In this paper, we outline the current progress in aging intervention studies using nutraceuticals from an evolutionary perspective in invertebrate models.
衰老是一个复杂且不可避免的生物学过程，与许多慢性衰弱性健康影响有关。开发有效的干预措施来促进健康衰老，是一个活跃但具有挑战性的研究领域。在各种模式生物（尤其是两种无脊椎动物秀丽隐杆线虫和黑腹果蝇）中的机制研究，已经确定了许多基因和途径，以及饮食干预措施，这些可以调节寿命和健康寿命。这些研究揭示了一些与衰老过程相关的机制，并为开发有效的衰老干预措施提供了有价值的指导。来自各种植物的营养保健品含有大量具有多种生物活性的植物化学物质。植物化学物质可以调节许多信号通路，发挥许多健康益处，如降低癌症发病率和炎症，并促进健康衰老。在本文中，我们从进化的角度概述了使用无脊椎动物模型中的营养保健品进行衰老干预研究的最新进展。
