[络石藤中痕量化学成分及其结构鉴定]

[Trace chemical constituents contained in Trachelospermum jasminoides and structure identification].

作者信息

Jing Ling, Yu Nengjiang, Zhao Yimin, Li Yushan

机构信息

Institute of Pharmacology and Toxicology, Academy of Military Medical sciences, Beijing 100850, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1581-5.

PMID:22993985

Abstract

OBJECTIVE

To study trace chemical constituents contained in traditional Chinese medicine Trachelospermum jasminoides.

METHOD

The chemical constituents were separated and purified by using such column chromatographic methods as ployamide, silica gel, Sephadex LH-20 and ODS, and their structures were identified on the basis of spectral data analysis.

RESULT

Eleven compounds were separated from T. jasminoides and identified as bergenin (1), chrysoeriol-7-O-beta-D-glucoside (2), arctigenin-4'-O-beta-gentiobioside (3), matairesinol 4'-O-beta-gentiobioside (4), traxillagenin (5), traxillaside (6), 4-demethyltraxillagenin (7), luteolin-7-O-beta-gentiobioside (8), arctiin (9), trachelogenin-4'-O-beta-gentiobioside (10) and luteolin-7-O-beta-D-glucoside (11).

CONCLUSION

Compounds 1 and 2 were separated from Trachelospermum genus for the first time, while compounds 3-7 were separated from this plant for the first time.

摘要

目的

研究中药络石藤中所含的痕量化学成分。

方法

采用聚酰胺、硅胶、葡聚糖凝胶LH - 20和十八烷基硅烷键合硅胶等柱色谱方法对化学成分进行分离纯化，并通过光谱数据分析鉴定其结构。

结果

从络石藤中分离得到11个化合物，分别鉴定为岩白菜素（1）、 Chrysoeriol - 7 - O - β - D - 葡萄糖苷（2）、牛蒡子苷元 - 4'- O - β - 龙胆二糖苷（3）、罗汉松脂素4'- O - β - 龙胆二糖苷（4）、络石苷元（5）、络石糖苷（6）、4 - 去甲基络石苷元（7）、木犀草素 - 7 - O - β - 龙胆二糖苷（8）、牛蒡子苷（9）、络石皂苷元 - 4'- O - β - 龙胆二糖苷（10）和木犀草素 - 7 - O - β - D - 葡萄糖苷（11）。