Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.
Neuron. 2012 Sep 20;75(6):1001-7. doi: 10.1016/j.neuron.2012.08.015.
Sleep is composed of an alternating sequence of REM and non-REM episodes, but their respective roles are not known. We found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increase in the recruitment of neuronal spiking to brief "ripple" episodes, resulting in a net increase in neural synchrony. Unexpectedly, within non-REM episodes, overall firing rates gradually increased together with a decrease in the recruitment of spiking to ripples. The rate increase within non-REM episodes was counteracted by a larger and more rapid decrease of discharge frequency within the interleaved REM episodes. Both the decrease in firing rates and the increase in synchrony during the course of sleep were correlated with the power of theta activity during REM episodes. These findings assign a prominent role of REM sleep in sleep-related neuronal plasticity.
睡眠由 REM 和非 REM 期的交替序列组成，但它们各自的作用尚不清楚。我们发现，随着短暂的“涟漪”事件中神经元尖峰募集的增加，海马 CA1 神经元的整体放电率在睡眠过程中下降，导致神经同步性净增加。出乎意料的是，在非 REM 期内，整体放电率逐渐增加，而向涟漪募集的尖峰减少。非 REM 期内的这种速率增加被 REM 期内放电频率的更大和更快的减小所抵消。在睡眠过程中，放电率的降低和同步性的增加都与 REM 期 theta 活动的功率相关。这些发现赋予了 REM 睡眠在与睡眠相关的神经元可塑性中重要作用。
