• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

益生菌和益生元对免疫系统的影响。

The impact of probiotics and prebiotics on the immune system.

机构信息

Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, Raleigh, North Carolina 27695, USA.

出版信息

Nat Rev Immunol. 2012 Oct;12(10):728-34. doi: 10.1038/nri3312.

DOI:10.1038/nri3312
PMID:23007572
Abstract

Probiotics and prebiotics are increasingly being added to foodstuffs with claims of health benefits. Probiotics are live microorganisms that are thought to have beneficial effects on the host, whereas prebiotics are ingredients that stimulate the growth and/or function of beneficial intestinal microorganisms. But can these products directly modulate immune function and influence inflammatory diseases? Here, Nature Reviews Immunology asks four experts to discuss these issues and provide their thoughts on the future application of probiotics as a disease therapy.

摘要

益生菌和益生元越来越多地被添加到食品中,并声称具有健康益处。益生菌是被认为对宿主有益的活微生物,而益生元是刺激有益肠道微生物生长和/或功能的成分。但是,这些产品是否可以直接调节免疫功能并影响炎症性疾病?在这里,《自然评论免疫学》邀请四位专家讨论这些问题,并就益生菌作为疾病治疗的未来应用提出他们的看法。

相似文献

1
The impact of probiotics and prebiotics on the immune system.益生菌和益生元对免疫系统的影响。
Nat Rev Immunol. 2012 Oct;12(10):728-34. doi: 10.1038/nri3312.
2
Probiotics and prebiotics associated with aquaculture: A review.与水产养殖相关的益生菌和益生元:综述
Fish Shellfish Immunol. 2015 Aug;45(2):733-41. doi: 10.1016/j.fsi.2015.05.038. Epub 2015 Jun 1.
3
Mechanisms and immunomodulatory properties of pre- and probiotics.益生菌和益生元的作用机制和免疫调节特性。
Benef Microbes. 2019 Apr 19;10(3):225-236. doi: 10.3920/BM2018.0066. Epub 2019 Mar 4.
4
Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases.肠道微生物群、益生菌和益生元在心血管疾病中的作用。
Molecules. 2021 Feb 22;26(4):1172. doi: 10.3390/molecules26041172.
5
Probiotics and prebiotics in non-bovine milk.非牛乳制品中的益生菌和益生元。
Adv Food Nutr Res. 2020;94:339-384. doi: 10.1016/bs.afnr.2020.06.008. Epub 2020 Jul 21.
6
Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings.益生菌和益生元的降胆固醇作用:体内和体外研究结果综述
Int J Mol Sci. 2010 Jun 17;11(6):2499-522. doi: 10.3390/ijms11062499.
7
Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence.益生元、益生菌、合生菌与免疫系统:实验数据与临床证据。
Curr Opin Gastroenterol. 2015 Mar;31(2):153-8. doi: 10.1097/MOG.0000000000000151.
8
[Probiotics and prebiotics as a bioactive component of functional food].[益生菌和益生元作为功能性食品的生物活性成分]
Pediatr Endocrinol Diabetes Metab. 2012;18(2):79-83.
9
Probiotics, prebiotics, and synbiotics: impact on the gut immune system and allergic reactions.益生菌、益生元和合生菌:对肠道免疫系统和过敏反应的影响。
J Leukoc Biol. 2011 May;89(5):685-95. doi: 10.1189/jlb.1109753. Epub 2011 Jan 13.
10
Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges.食用益生菌和益生元对健康影响的科学证据:当前观点与未来挑战的最新情况
Br J Nutr. 2015 Dec 28;114(12):1993-2015. doi: 10.1017/S0007114515003864. Epub 2015 Oct 7.

引用本文的文献

1
Uncovering encrypted antimicrobial peptides in health-associated Lactobacillaceae by large-scale genomics and machine learning.通过大规模基因组学和机器学习揭示健康相关乳酸菌科中加密的抗菌肽
Microbiome. 2025 Jun 21;13(1):151. doi: 10.1186/s40168-025-02145-3.
2
Beyond the tumor: the gut microbiome as a key player in immunotherapy efficacy and resistance.肿瘤之外:肠道微生物群在免疫治疗疗效和耐药性中起关键作用
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 3. doi: 10.1007/s00210-025-04315-4.
3
The natural symbiotic bacterium Enterococcus faecalis LX10 drives Bombyx mori refractoriness to Nosema bombycis infection via the secretion of enterococcin.

本文引用的文献

1
Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.通过缺失脂磷壁酸的嗜酸乳杆菌来减少结肠息肉。
Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7. doi: 10.1073/pnas.1207230109. Epub 2012 Jun 11.
2
A meta-analysis of probiotic efficacy for gastrointestinal diseases.益生菌治疗胃肠道疾病的疗效的荟萃分析。
PLoS One. 2012;7(4):e34938. doi: 10.1371/journal.pone.0034938. Epub 2012 Apr 18.
3
Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.
天然共生细菌粪肠球菌LX10通过分泌肠球菌素使家蚕对家蚕微孢子虫感染产生抗性。
BMC Microbiol. 2025 May 17;25(1):303. doi: 10.1186/s12866-025-03980-y.
4
Comparative genome analysis of the immunomodulatory ability of and from Japanese pickles.日本泡菜中[具体物质1]和[具体物质2]免疫调节能力的比较基因组分析。
mSystems. 2025 May 20;10(5):e0157524. doi: 10.1128/msystems.01575-24. Epub 2025 Apr 29.
5
Whole Genome Analysis of XJ-24 and Its Role in Preventing ATCC 19115 Infection in C57BL/6 Mice.XJ-24的全基因组分析及其在预防C57BL/6小鼠感染ATCC 19115中的作用
Antibiotics (Basel). 2025 Mar 19;14(3):323. doi: 10.3390/antibiotics14030323.
6
The Effect of Prebiotics and Probiotics on Levels of Depression, Anxiety, and Cognitive Function: A Meta-Analysis of Randomized Clinical Trials.益生元和益生菌对抑郁、焦虑及认知功能水平的影响:一项随机临床试验的荟萃分析
Brain Behav. 2025 Mar;15(3):e70401. doi: 10.1002/brb3.70401.
7
Exploring the anti-inflammatory effects of microencapsulated probiotic bacteria: in vivo and in vitro evaluation in healthy mouse models.探索微囊化益生菌的抗炎作用:在健康小鼠模型中的体内和体外评价
J Sci Food Agric. 2025 May;105(7):3753-3759. doi: 10.1002/jsfa.14162. Epub 2025 Jan 31.
8
Action and immunomodulatory mechanisms, formulations, and safety concerns of probiotics.益生菌的作用、免疫调节机制、制剂及安全性问题
Biosci Microbiota Food Health. 2025;44(1):4-15. doi: 10.12938/bmfh.2024-006. Epub 2024 Aug 30.
9
Examining immune-inflammatory mechanisms of probiotic supplementation in depression: secondary findings from a randomized clinical trial.探究益生菌补充剂在抑郁症中的免疫炎症机制:一项随机临床试验的次要发现。
Transl Psychiatry. 2024 Jul 24;14(1):305. doi: 10.1038/s41398-024-03030-7.
10
Gut-directed therapy in Parkinson's disease.帕金森病的肠道定向治疗。
Front Pharmacol. 2024 Jun 21;15:1407925. doi: 10.3389/fphar.2024.1407925. eCollection 2024.
由乳杆菌分泌的乳链菌肽通过选择性降解促炎趋化因子发挥抗炎作用。
Cell Host Microbe. 2012 Apr 19;11(4):387-96. doi: 10.1016/j.chom.2012.02.006.
4
Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis.孕期或婴儿期补充益生菌预防特应性皮炎:荟萃分析。
Epidemiology. 2012 May;23(3):402-14. doi: 10.1097/EDE.0b013e31824d5da2.
5
Bifidobacterial surface-exopolysaccharide facilitates commensal-host interaction through immune modulation and pathogen protection.双歧杆菌表面胞外多糖通过免疫调节和病原体保护促进共生宿主相互作用。
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2108-13. doi: 10.1073/pnas.1115621109. Epub 2012 Jan 23.
6
Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model.益生菌和后生元在健康和疾病中的作用:新型极化体外器官培养模型的比较。
Gut. 2012 Jul;61(7):1007-15. doi: 10.1136/gutjnl-2011-300971. Epub 2012 Feb 1.
7
Efficacy of probiotics for the management of inflammatory bowel disease.益生菌对炎症性肠病的治疗效果。
Gastroenterol Hepatol (N Y). 2011 Sep;7(9):606-8.
8
The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG.主要分泌蛋白 Msp1/p75 在鼠李糖乳杆菌 GG 中发生 O-糖基化。
Microb Cell Fact. 2012 Feb 1;11:15. doi: 10.1186/1475-2859-11-15.
9
The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates.人体肠道微生物菌群受快速摄取和转化简单碳水化合物的驱动。
ISME J. 2012 Jul;6(7):1415-26. doi: 10.1038/ismej.2011.212. Epub 2012 Jan 19.
10
Probiotics for maintenance of remission in ulcerative colitis.用于维持溃疡性结肠炎缓解的益生菌。
Cochrane Database Syst Rev. 2011 Dec 7(12):CD007443. doi: 10.1002/14651858.CD007443.pub2.