巴西亚马逊地区同时患有登革热和间日疟原虫疟疾的临床特征：11 例住院患者的病例系列。
Clinical profile of concurrent dengue fever and Plasmodium vivax malaria in the Brazilian Amazon: case series of 11 hospitalized patients.
机构信息
Universidade do Estado do Amazonas, Manaus, Brazil.
出版信息
Am J Trop Med Hyg. 2012 Dec;87(6):1119-24. doi: 10.4269/ajtmh.2012.12-0210. Epub 2012 Oct 1.
Abstract
Malaria and dengue fever are the most prevalent vector-borne diseases worldwide. This study aims to describe the clinical profile of patients with molecular diagnosis of concurrent malaria and dengue fever in a tropical-endemic area. Eleven patients with concurrent dengue virus (DENV) and Plasmodium vivax infection are reported. Similar frequencies of DENV-2, DENV-3, and DENV-4 were found, including DENV-3/DENV-4 co-infection. In eight patients, the World Health Organization (WHO) criteria for severe malaria could be fulfilled (jaundice being the most common). Only one patient met severe dengue criteria, but warning signs were present in 10. Syndromic surveillance systems must be ready to identify this condition to avoid misinterpretation of severity attributed to a single disease.
摘要
疟疾和登革热是全球最普遍的虫媒传染病。本研究旨在描述热带流行地区经分子诊断为同时感染疟疾和登革热患者的临床特征。报告了 11 例登革病毒（DENV）和间日疟原虫混合感染的患者。发现 DENV-2、DENV-3 和 DENV-4 的频率相似，包括 DENV-3/DENV-4 共同感染。在 8 例患者中，符合世界卫生组织（WHO）重症疟疾标准（黄疸是最常见的）。只有 1 例患者符合重症登革热标准，但 10 例患者存在预警信号。症状监测系统必须做好准备识别这种情况，以避免因单一疾病而导致的严重程度的误解。
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