Interdepartmental Division of Critical Care Medicine, University of Toronto, and the Division of Respirology, Department of Medicine, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada.
BMC Med. 2012 Oct 3;10:115. doi: 10.1186/1741-7015-10-115.
Intensive care unit-acquired weakness (ICUAW) has been recognized as an important and persistent complication in survivors of critical illness. The absence of a consistent nomenclature and diagnostic criteria for ICUAW has made research in this area challenging. Although many risk factors have been identified, the data supporting their direct association have been controversial. Presently, there is a growing body of literature supporting the utility and benefit of early mobility in reducing the morbidity from ICUAW, but few centers have adopted this into their ICU procedures. Ultimately, the implementation of such a strategy would require a shift in the knowledge and culture within the ICU, and may be facilitated by novel technology and patient care strategies. The purpose of this article is to briefly review the diagnosis, risk factors, and management of ICUAW, and to discuss some of the barriers and novel treatments to improve outcomes for our ICU survivors.
重症监护病房获得性肌无力（ICUAW）已被认为是危重病幸存者的一个重要且持久的并发症。由于缺乏 ICUAW 的一致命名法和诊断标准，使得该领域的研究具有挑战性。尽管已经确定了许多危险因素，但支持其直接关联的数据存在争议。目前，越来越多的文献支持早期活动在降低 ICUAW 发病率方面的效用和益处，但很少有中心将其纳入 ICU 程序。最终，实施这样的策略需要改变 ICU 内部的知识和文化，而新技术和患者护理策略可能会为此提供帮助。本文的目的是简要回顾 ICUAW 的诊断、危险因素和治疗，并讨论一些改善 ICU 幸存者预后的障碍和新的治疗方法。
