Kurokawa Kazuhiro, Sasaki Kazuhiro, Makita Shuichi, Hong Young-Joo, Yasuno Yoshiaki
Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
Opt Express. 2012 Sep 24;20(20):22796-812. doi: 10.1364/OE.20.022796.
Retinal and choroidal vascular imaging is a key to the better understanding and diagnosis of eye diseases. To achieve comprehensive three-dimensional capillary imaging, we used an enhanced vascular imaging technique, so called adaptive optics optical coherence angiography (AO-OCA). AO-OCA enables in vivo high-resolution and high-contrast micro-vascular imaging by detecting Doppler frequency shifts. Using this technique, the retinal and choroidal vasculatures of healthy subjects were imaged. The results show that both intensity and Doppler power images have sufficient contrast to discriminate almost all vasculatures from the static tissue. However, the choriocapillaris, pre-arterioles, and post-venules in the Sattler layer were more contrasted by the Doppler technique. In conclusion, AO-OCA enables three-dimensional capillary imaging, and is especially useful for the detection of the choriocapillaris and choroidal capillary network.
视网膜和脉络膜血管成像对于更好地理解和诊断眼部疾病至关重要。为了实现全面的三维毛细血管成像，我们采用了一种增强型血管成像技术，即自适应光学光学相干血管造影（AO-OCA）。AO-OCA通过检测多普勒频移实现体内高分辨率和高对比度微血管成像。利用该技术，对健康受试者的视网膜和脉络膜血管系统进行了成像。结果表明，强度图像和多普勒功率图像都具有足够的对比度，能够将几乎所有血管与静态组织区分开来。然而，采用多普勒技术时，萨特勒层中的脉络膜毛细血管、小动脉前支和小静脉后支的对比度更高。总之，AO-OCA能够实现三维毛细血管成像，尤其有助于检测脉络膜毛细血管和脉络膜毛细血管网。
