前列腺素D2，一种神经调质。
Prostaglandin D2, a neuromodulator.
作者信息
Shimizu T, Mizuno N, Amano T, Hayaishi O
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6231-4. doi: 10.1073/pnas.76.12.6231.
Abstract
The distribution of prostaglandin D synthetase activity was determined in various tissues of rat by using the supernatant fraction (10,000 x g, 20 min) of the homogenates. The highest activity was found in brain, spinal cord, and alimentary tract. The activity was uniquitously distributed in all parts of brain, and the highest specific activity was found in hypothalamus and thalamus. Homogenates of two neuroblastoma cell lines were found to produce prostaglandin D2, whereas a glioma cell line was almost inactive. Prostaglandin D2 is a potent and specific activator of the adenylate cyclase system of cultured neuroblastoma cells, suggesting the possibility that it may act as a neuromodulator in the central nervous system.
摘要
通过使用匀浆的上清液部分（10,000×g，20分钟）来测定大鼠各种组织中前列腺素D合成酶的活性分布。在脑、脊髓和消化道中发现活性最高。该活性在脑的所有部位均有分布，且在下丘脑和丘脑发现了最高的比活性。发现两种神经母细胞瘤细胞系的匀浆可产生前列腺素D2，而一种胶质瘤细胞系几乎无活性。前列腺素D2是培养的神经母细胞瘤细胞腺苷酸环化酶系统的强效特异性激活剂，这表明它可能在中枢神经系统中作为神经调节剂发挥作用。
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