大剂量肾上腺素可降低兔全身麻醉下的骨骼肌血流。
Large-dose epinephrine reduces skeletal muscle blood flow under general anesthesia in rabbits.
作者信息
Terakawa Yui, Ichinohe Tatsuya
机构信息
NTT Medical Center Tokyo, Tokyo, Japan.
出版信息
Anesth Prog. 2012 Fall;59(3):118-22. doi: 10.2344/12-00006.1.
The goal of this study was to investigate the effect of an epinephrine continuous infusion on muscle blood flow in rabbits. Sixteen male Japan White rabbits were randomly allocated to 1 of 2 groups: epinephrine continuous infusion at 0.01 μg/kg/min (Ep-0.01 group, n = 8) and at 0.1 μg/kg/ min (Ep-0.1 group, n = 8). The observed variables were heart rate, femoral artery blood pressure, common carotid artery blood flow (CCBF), masseter muscle blood flow (MBF), and quadriceps muscle blood flow (QBF). In the Ep-0.01 group, CCBF, MBF, and QBF were increased by 14, 22, and 21% from respective control values. In contrast, in the Ep-0.1 group, CCBF, MBF and QBF were decreased by 10, 30, and 27% from respective control values. There were no differences in the percentage change between MBF and QBF during epinephrine continuous infusion. Positive correlations were observed between CCBF and MBF and between CCBF and QBF. In conclusion, skeletal muscle blood flow was increased during the small-dose epinephrine infusion, whereas it was decreased during large-dose infusion.
本研究的目的是探讨肾上腺素持续输注对兔肌肉血流的影响。将16只雄性日本白兔随机分为2组中的1组：以0.01μg/kg/min的速度持续输注肾上腺素（Ep-0.01组，n = 8）和以0.1μg/kg/min的速度持续输注肾上腺素（Ep-0.1组，n = 8）。观察变量包括心率、股动脉血压、颈总动脉血流（CCBF）、咬肌血流（MBF）和股四头肌血流（QBF）。在Ep-0.01组中，CCBF、MBF和QBF分别较各自的对照值增加了14%、22%和21%。相比之下，在Ep-0.1组中，CCBF、MBF和QBF分别较各自的对照值降低了10%、30%和27%。在肾上腺素持续输注期间，MBF和QBF的变化百分比无差异。观察到CCBF与MBF之间以及CCBF与QBF之间呈正相关。总之，小剂量肾上腺素输注期间骨骼肌血流增加，而大剂量输注期间则减少。
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