Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul, Korea.
Neurochem Res. 2013 Jan;38(1):117-22. doi: 10.1007/s11064-012-0897-8. Epub 2012 Oct 4.
The synergic effect of regular exercise and resveratrol, a polyphenolic compound with potent antioxidant activity, was investigated against kainate-induced seizures and oxidative stress in mice. After 6 weeks of swimming training, the total body weight decreased and the blood concentration of lactate stabilized statistically in comparison with the sedentary mice, indicate that the training program increased the aerobic resistance of mice. Kainate (30 mg/kg) evoked seizure activity 5 min after injection, and seizure activity was measured seizure rating scores every 5 min up to 2 h. As previously well known experiments, regular exercise and resveratrol (40 mg/kg, daily supplementation for 6 weeks) have an inhibitory effect on kainate-induced seizure activity and oxidative stress. In particularly, a synergistic cooperation of regular exercise and resveratrol was observed in seizure activity, mortality and oxidative stress especially in SOD activity. These results suggest that regular exercise along with an anti-convulsant agent such as resveratrol could be a more efficient method for the prevention of seizure development than exercise alone.
本研究旨在探讨规律运动与白藜芦醇（一种具有强大抗氧化活性的多酚化合物）的协同作用，观察其对鼠科动物海人酸诱导的癫痫发作和氧化应激的影响。经过 6 周的游泳训练，与久坐不动的小鼠相比，总体重减轻，血液中乳酸浓度稳定，这表明训练计划提高了小鼠的有氧耐力。海人酸（30mg/kg）注射后 5 分钟诱发癫痫发作，每隔 5 分钟测量一次癫痫发作评分，直至 2 小时。如之前的实验所示，规律运动和白藜芦醇（40mg/kg，每日补充 6 周）对海人酸诱导的癫痫发作和氧化应激具有抑制作用。特别是，在癫痫发作、死亡率和氧化应激（尤其是 SOD 活性）方面，观察到了规律运动和白藜芦醇的协同作用。这些结果表明，与单独运动相比，规律运动与抗惊厥药物（如白藜芦醇）结合可能是预防癫痫发作发展的更有效方法。
