Department of Psychology and Neuroscience, University of Colorado, Boulder, Colorado 80309-0345, USA.
J Neurosci. 2012 Oct 10;32(41):14118-24. doi: 10.1523/JNEUROSCI.3340-12.2012.
Safety signals are learned cues that predict the nonoccurrence of an aversive event. As such, safety signals are potent inhibitors of fear and stress responses. Investigations of safety signal learning have increased over the last few years due in part to the finding that traumatized persons are unable to use safety cues to inhibit fear, making it a clinically relevant phenotype. The goal of this review is to present recent advances relating to the neural and behavioral mechanisms of safety learning, and expression in rodents, nonhuman primates, and humans.
安全信号是预测不愉快事件发生的学习线索。因此，安全信号是抑制恐惧和应激反应的有效抑制剂。由于发现创伤后个体无法使用安全线索抑制恐惧，这是一种具有临床相关性的表型，因此近年来对安全信号学习的研究有所增加。本文的目的是介绍与安全学习的神经和行为机制及其在啮齿动物、非人灵长类动物和人类中的表达相关的最新进展。
