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Obstructing toxin pathways by targeted pore blockage.

作者信息

Nestorovich Ekaterina M, Bezrukov Sergey M

机构信息

Department of Biology, The Catholic University of America, Washington, DC 20064, United States.

出版信息

Chem Rev. 2012 Dec 12;112(12):6388-430. doi: 10.1021/cr300141q. Epub 2012 Oct 11.

DOI:10.1021/cr300141q
PMID:23057504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3681896/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/8a36ff8f54c0/nihms-449377-f0069.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/6d754a94ffc3/nihms-449377-f0042.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/00b7fd326663/nihms-449377-f0046.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/3bdcefa851e0/nihms-449377-f0048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/fb05801b130d/nihms-449377-f0049.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/769c1c24db2f/nihms-449377-f0050.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/6ed80dd6e2a9/nihms-449377-f0041.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/6d754a94ffc3/nihms-449377-f0042.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/a713a1ac529a/nihms-449377-f0043.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/3bdcefa851e0/nihms-449377-f0048.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/fb05801b130d/nihms-449377-f0049.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/769c1c24db2f/nihms-449377-f0050.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/2916c27108cf/nihms-449377-f0051.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/ada522279e9e/nihms-449377-f0052.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/0594f79a7310/nihms-449377-f0053.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/f603edfb4041/nihms-449377-f0054.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/dc0c53ebcaae/nihms-449377-f0055.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/c7e9afd6b9d6/nihms-449377-f0056.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/c13c3c91ac62/nihms-449377-f0057.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/835f3f282883/nihms-449377-f0058.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/003f6ded7562/nihms-449377-f0059.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/4256d375e7da/nihms-449377-f0060.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/8edc954fcb98/nihms-449377-f0061.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/98923de8c435/nihms-449377-f0062.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/beaf75eb0ee6/nihms-449377-f0063.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/aac6c3837875/nihms-449377-f0064.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/278878ce19db/nihms-449377-f0065.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/3140c95cce49/nihms-449377-f0066.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/0f664653f3f7/nihms-449377-f0067.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/66a284cd3280/nihms-449377-f0068.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40d9/3681896/8a36ff8f54c0/nihms-449377-f0069.jpg

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Reading DNA at single-nucleotide resolution with a mutant MspA nanopore and phi29 DNA polymerase.利用突变型 MspA 纳米孔和 phi29 DNA 聚合酶实现单核苷酸分辨率下的 DNA 读取。
Nat Biotechnol. 2012 Mar 25;30(4):349-53. doi: 10.1038/nbt.2171.
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Targeting bacterial toxins.靶向细菌毒素。
孔形成蛋白的抑制作用。
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Blocker escape kinetics from a membrane channel analyzed by mapping blocker diffusive dynamics onto a two-site model.通过将阻滞剂扩散动力学映射到双位点模型来分析膜通道的阻滞剂逃逸动力学。
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