肥胖：与孕期营养有关的跨代问题。
Obesity: a transgenerational problem linked to nutrition during pregnancy.
机构信息
Department of Obstetrics and Gynecology, Oregon Health and Science University (OHSU) Portland, Oregon 97239, USA.
出版信息
Semin Reprod Med. 2012 Dec;30(6):472-8. doi: 10.1055/s-0032-1328875. Epub 2012 Oct 16.
Abstract
The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.
摘要
母亲肥胖导致的产科风险已得到充分描述。这些风险包括妊娠糖尿病、先兆子痫、死产和剖宫产的风险增加。产前母亲肥胖对胎儿/新生儿的影响则受到较少关注。除了死产风险增加之外，胎儿/新生儿的后果还包括肥胖增加和代谢状态，这会增加肥胖和糖尿病的终生风险。这篇综述重点介绍了母亲肥胖的临床产科后果，并强调了最近关于胎儿编程的机制见解，以及有证据表明产前保健提供了一个独特的机会来改善这些风险，并减少儿童肥胖的循环。
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