Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
J Am Chem Soc. 2012 Oct 31;134(43):17862-5. doi: 10.1021/ja3079972. Epub 2012 Oct 19.
Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H(2)O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs, whereas m-SWNTs produced heat more efficiently than s-SWNTs. More importantly, cancer cell killing by PDE of s-SWNTs has been disclosed for the first time.
半导体和金属单壁碳纳米管（s-SWNTs 和 m-SWNTs）通过琼脂糖凝胶色谱法进行富集，并在 H（2）O 中比较它们的光热和光动力效应。在近红外激光照射下，s-SWNTs 产生的活性氧物质（ROS）多于 m-SWNTs，而 m-SWNTs 比 s-SWNTs 更有效地产生热量。更重要的是，首次揭示了 s-SWNTs 的 PDE 对癌细胞的杀伤作用。
