Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Eur J Nutr. 2013 Aug;52(5):1493-501. doi: 10.1007/s00394-012-0456-8. Epub 2012 Oct 25.
To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers.
Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis.
Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin.
In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.
报告居住在欧洲多个国家的老年人的血浆/血清抗氧化维生素和类胡萝卜素水平，并研究其与潜在修饰因子的关系。
这是一项在欧洲北部和南部 7 个中心进行的基于人群的欧洲眼研究的横断面研究。共招募了 4133 名年龄在 65 岁及以上、通过随机抽样收集的参与者。问卷调查涉及饮食、生活方式和病史。在一个单一的实验室中分析非禁食血液样本，以检测维生素 A、C 和 E 以及一组类胡萝卜素。通过bootstrap 多变量回归分析来分析相关性。
中心和季节影响所有抗氧化维生素和类胡萝卜素的血清和血浆浓度。性别、BMI、吸烟、年龄、教育、饮酒和补充剂的使用也与一些，但不是所有，所检查的抗氧化维生素和类胡萝卜素有显著相关性。解释的方差比例范围从视黄醇的 4.8%到玉米黄质的 25.2%。
在老年人中，抗氧化维生素和类胡萝卜素的状态因中心和季节而异，但也与其他行为和生活方式变量有关。旨在证明抗氧化维生素和类胡萝卜素状态与慢性疾病风险之间存在关联的研究应考虑这些潜在的混杂因素。
