Departamento de Química, Universidad Técnica Federico Santa María, Av. España No. 1680, Valparaíso, Chile.
J Ethnopharmacol. 2012 Dec 18;144(3):809-11. doi: 10.1016/j.jep.2012.10.027. Epub 2012 Oct 23.
Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus.
To evaluate the in vitro antifungal activity of the resin and the active components from P. glandulosa against clinical yeast isolates.
Active compounds were obtained of the resinous exudate from aerial parts of P. glandulosa. Eight species of yeast were exposed to the resin and two major compounds. Minimum inhibitory concentration (MIC(80)) was determined according to the standard broth microdilution method.
Bakuchiol and 3-hydroxy-bakuchiol demonstrated potent activity with the MIC(80) ranging from 4 to >16 and 0.125 to 16 μg/mL, respectively. The resin had some degree of antifungal activity.
The overall results provided important information for the potential application of the 3-hydroxy-bakuchiol from P. glandulosa in the therapy of serious infection and skin diseases caused by clinical yeast.
Psoralea glandulosa L.（豆科）是一种药用树脂灌木，在智利民间医学中被用作防腐剂，用于治疗细菌和真菌感染引起的感染和皮肤病。
评估树脂和来自 P. glandulosa 的活性成分对临床酵母分离株的体外抗真菌活性。
从 P. glandulosa 的地上部分获得树脂状渗出物的活性化合物。将八种酵母暴露于树脂和两种主要化合物中。根据标准肉汤微量稀释法测定最小抑菌浓度（MIC(80)）。
Bakuchiol 和 3-羟基 Bakuchiol 表现出很强的活性，MIC(80) 分别为 4 至>16 和 0.125 至 16 μg/mL。树脂具有一定程度的抗真菌活性。
总体结果为 3-羟基 Bakuchiol 来自 P. glandulosa 在治疗由临床酵母引起的严重感染和皮肤疾病方面的潜在应用提供了重要信息。
