Department of Ophthalmology, Faculty of Medicine, Université.
Invest Ophthalmol Vis Sci. 2012 Nov 27;53(12):7819-24. doi: 10.1167/iovs.12-9834.
To measure the pulsatile movement of neuroretinal tissue at the optic nerve head synchronous with the cardiac cycle.
We used a noninvasive imaging device based on Fourier domain low-coherence interferometry to measure the pulsatile movements of the optic nerve head, peripapillary retina, and cornea with submicron accuracy along a line across the fundus. We also measured the change in the Axial Distance between the peripapillary Retina and the base of the optic disc Cup (ADRC) during the cardiac cycle. Twelve normal subjects and 20 subjects with open-angle glaucoma were tested.
In normal subjects, the mean fundus pulsation amplitude (defined as the fundus movement minus the simultaneous corneal movement) were 13.0 ± 2.5 μm, 9.0 ± 2.1 μm, and 8.7 ± 2.9 μm at the base of the optic nerve head cup, the nasal peripapillary retina, and the temporal peripapillary retina, respectively, compared with 16.7 ± 6.8 μm, 17.3 ± 10.9 μm, and 12.7 ± 6.2 μm for the corresponding values in the glaucoma group (P = 0.26, P = 0.008, and P = 0.12, respectively). The mean changes in ADRC during the cardiac cycle in normal subjects were 10.7 ± 2.1 μm and 11.6 ± 1.8 μm for the nasal and temporal side of the optic disc, respectively, compared to 14.9 ± 5.6 μm and 14.0 ± 4.9 μm in glaucoma subjects (P = 0.03 and P = 0.10, respectively).
There was an approximately 11-μm pulsatile change in the ADRC in normal subjects, and on the nasal side of the disc, this amount was significantly greater in glaucoma patients.
测量视神经头神经视网膜组织的脉动运动，与心脏周期同步。
我们使用一种基于傅里叶域低相干干涉测量的非侵入性成像设备，以亚微米精度测量眼底的视神经头、视盘周围视网膜和角膜的脉动运动。我们还测量了心动周期中视盘周围视网膜和视盘底部杯（ADRC）之间轴向距离的变化。测试了 12 名正常受试者和 20 名开角型青光眼患者。
在正常受试者中，视神经头杯底部、鼻侧视盘周围视网膜和颞侧视盘周围视网膜的平均眼底脉动振幅（定义为眼底运动减去同时的角膜运动）分别为 13.0 ± 2.5μm、9.0 ± 2.1μm 和 8.7 ± 2.9μm，而青光眼组的相应值分别为 16.7 ± 6.8μm、17.3 ± 10.9μm 和 12.7 ± 6.2μm（P = 0.26、P = 0.008 和 P = 0.12）。正常受试者心动周期中 ADRC 的平均变化在视盘鼻侧和颞侧分别为 10.7 ± 2.1μm 和 11.6 ± 1.8μm，而青光眼患者分别为 14.9 ± 5.6μm 和 14.0 ± 4.9μm（P = 0.03 和 P = 0.10）。
正常受试者的 ADRC 有一个大约 11μm 的脉动变化，在视盘的鼻侧，这个量在青光眼患者中明显更大。
