Dipartimento di Patologia e Sanità Animale, Sezione Malattie Infettive, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
Dipartimento di Patologia e Sanità Animale, Sezione Patologia Generale, Facoltà di Medicina Veterinaria, Università di Napoli Federico II, Napoli, Italy.
J Gen Virol. 2013 Feb;94(Pt 2):403-408. doi: 10.1099/vir.0.047662-0. Epub 2012 Oct 24.
Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) β receptor in a double-colour immunofluorescence assay. Our results indicate that the E5-PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes.
牛乳头瘤病毒 2 型（BPV-2）已被证明会感染并在土耳其马尔马拉和黑海地区放牧的水牛的膀胱癌发生中发挥作用。在膀胱癌的肿瘤和非肿瘤病变中均发现了 BPV-2 DNA。此外，由于在临床正常的水牛中也检测到了 BPV-2 DNA，因此该病毒可能是膀胱的正常居民。蕨类植物免疫抑制剂或致癌物质的病毒激活可能会引发尿路上皮细胞的转化。E5 癌蛋白仅在尿路上皮肿瘤中被检测到，并且似乎在双色免疫荧光测定中与过表达和磷酸化的血小板衍生生长因子（PDGF）β受体共定位。我们的研究结果表明，E5-PDGFβ受体相互作用也发生在水牛的自发性膀胱肿瘤中，揭示了 BPV-2 在水牛膀胱癌发生中的另一个作用。
