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生物宝藏宏基因组:为大科学铺平道路。

A biological treasure metagenome: pave a way for big science.

机构信息

Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Yongbong-Dong, Buk-Gu, Gwangju, 500-757 Korea.

出版信息

Indian J Microbiol. 2008 Jun;48(2):163-72. doi: 10.1007/s12088-008-0030-5. Epub 2008 Jul 27.

DOI:10.1007/s12088-008-0030-5
PMID:23100711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3450180/
Abstract

The trend of recent researches, in which synthetic biology and white technology through system approaches based on "Omics technology" are recognized as the ground of biotechnology, indicates the coming of the 'metagenome era' that accesses the genomes of all microbes aiming at the understanding and industrial application of the whole microbial resources. The remarkable advance of technologies for digging out and analyzing metagenome is enabling not only practical applications of metagenome but also system approaches on a mixed-genome level based on accumulated information. In this situation, the present review is purposed to introduce the trends and methods of research on metagenome and to examine big science led by related resources in the future.

摘要

最近的研究趋势表明,合成生物学和白色技术通过基于“组学技术”的系统方法被认为是生物技术的基础,这预示着“宏基因组时代”的到来,该时代旨在通过挖掘和分析宏基因组的技术取得了显著进展,不仅使宏基因组的实际应用成为可能,而且还基于积累的信息在混合基因组水平上实现了系统方法。在这种情况下,本文旨在介绍宏基因组的研究趋势和方法,并考察未来相关资源引领的大科学。

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本文引用的文献

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A novel retrieval system for nearly complete microbial genomic fragments from soil samples.一种用于从土壤样本中检索近乎完整微生物基因组片段的新型系统。
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Predicting protein function from sequence and structure.从序列和结构预测蛋白质功能。
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Nature. 2007 Oct 18;449(7164):811-8. doi: 10.1038/nature06245.
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Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.从培养和未培养细菌基因组中回收的含isnA生物合成基因簇的天然产物。
J Am Chem Soc. 2007 Oct 10;129(40):12102-3. doi: 10.1021/ja075492v. Epub 2007 Sep 19.
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Genome transplantation in bacteria: changing one species to another.细菌中的基因组移植:将一个物种转变为另一个物种。
Science. 2007 Aug 3;317(5838):632-8. doi: 10.1126/science.1144622. Epub 2007 Jun 28.
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Metagenomic sorcery and the expanding protein universe.宏基因组学的魔力与不断扩展的蛋白质世界
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