Department of Clinical and Experimental Medicine, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Obes Facts. 2012;5(5):641-7. doi: 10.1159/000343507. Epub 2012 Oct 2.
The present study aimed to evaluate whether baseline insulin resistance (IR) modify weight change associated to glycemic index (GI) of the diet.
This is a secondary analysis of a randomized GI intervention according to baseline HOMA-IR. Middle-aged (25-45 years), non-obese (BMI 23-29.9 kg/m²) women were randomized to low or high GI diets matched on total energy, macronutrient composition, and fiber content. Both groups received dietary counseling based on a small energy restriction (100-300 kcal/day). Women were classified in two groups according to their baseline HOMA-IR: IR (n = 64) and non-IR (n = 121).
At baseline, IR and non-IR groups had similar BMI (26.7 vs. 26.3 kg/m²; p = 0.21), but the IR group presented with higher waist circumference (82.7 vs. 80.8 cm; p = 0.02) and showed greater weight loss after 12 months of follow-up (-1.6 vs. -1.1 kg; p = 0.01), mainly among those in a high-GI diet (-2.1 vs. -1.0 kg; p = 0.005) compared to the non-IR group (-1.4 vs. -0.8 kg; p = 0.04).
The high-GI group showed statistically significant higher reduction in body weight, mainly among those women with baseline IR . Low-GI diet did not facilitate weight loss neither in IR women nor in non-IR women.
本研究旨在评估基线胰岛素抵抗（IR）是否会改变与饮食血糖指数（GI）相关的体重变化。
这是一项根据基线 HOMA-IR 对 GI 干预进行的二次分析。中年（25-45 岁）、非肥胖（BMI 23-29.9 kg/m²）女性根据基线 HOMA-IR 被随机分为低或高 GI 饮食组，两组的总能量、宏量营养素组成和纤维含量相匹配。两组均接受基于小能量限制（100-300 kcal/天）的饮食咨询。根据基线 HOMA-IR 将女性分为两组：IR 组（n = 64）和非 IR 组（n = 121）。
基线时，IR 和非 IR 组的 BMI 相似（26.7 与 26.3 kg/m²；p = 0.21），但 IR 组的腰围更大（82.7 与 80.8 cm；p = 0.02），且在 12 个月的随访后体重减轻更多（-1.6 与-1.1 kg；p = 0.01），主要发生在高 GI 饮食组中（-2.1 与-1.0 kg；p = 0.005），而非 IR 组中（-1.4 与-0.8 kg；p = 0.04）。
高 GI 组体重减轻的幅度具有统计学意义，主要发生在基线 IR 的女性中。低 GI 饮食既不能促进 IR 女性的体重减轻，也不能促进非 IR 女性的体重减轻。
