Agner T, Serup J
Department of Dermatology, Rigshospitalet, Copenhagen, Denmark.
Clin Exp Dermatol. 1990 Jan;15(1):29-33. doi: 10.1111/j.1365-2230.1990.tb02014.x.
A major purpose of irritant patch testing is to differentiate between normal, delicate and less sensitive skin. To assess the usefulness of irritant patch testing, knowledge of variation in responses to identical patch tests is essential. In the present study inter- and intra-individual variation in irritant patch test reactions due to sodium lauryl sulphate and nonanoic acid is given when evaluated by traditional visual scoring as well as different non-invasive methods, i.e. measurement of transepidermal water loss, the hydration state of stratum corneum by electrical conductance, cutaneous blood flow by laser Doppler flowmetry, and measurement of skin thickness by 20-MHz ultrasound A-scan. The intra-individual 'site-to-site' variation was considerably less than the inter-individual variation, which is essential to differentiate between persons with delicate and less sensitive skin. Methods used were relevant for this purpose except for the measurement of electrical conductance.
刺激性斑贴试验的一个主要目的是区分正常、敏感和不太敏感的皮肤。为了评估刺激性斑贴试验的有效性，了解对相同斑贴试验反应的变异性至关重要。在本研究中，当通过传统视觉评分以及不同的非侵入性方法进行评估时，给出了因十二烷基硫酸钠和壬酸引起的刺激性斑贴试验反应的个体间和个体内变异性，即经表皮水分流失的测量、通过电导率测量角质层的水合状态、通过激光多普勒血流仪测量皮肤血流量以及通过20兆赫超声A扫描测量皮肤厚度。个体内“部位间”的变异性明显小于个体间的变异性，这对于区分敏感皮肤和不太敏感皮肤的人至关重要。除了电导率测量外，所使用的方法对于此目的是相关的。
