Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P.R. China.
Lipids Health Dis. 2012 Oct 31;11:148. doi: 10.1186/1476-511X-11-148.
Atherosclerosis is a major manifestation of the pathophysiology underlying cardiovascular disease. Flaxseed oil (FO) and α-lipoic acid (LA) have been reported to exert potential benefit to cardiovascular system. This study tried to assess the effect of supplement of FO and LA combination on the atherosclerosis risk factors in rats fed a high-fat diet.
LA was dissolved in flaxseed oil to a final concentration of 8 g/kg (FO+LA) when used. The rodent diet contained 20% fat. One-fifth of the fat was soybean oil and the others were lard (HFD group), or 75% lard and 25% FO+LA (L-FO+LA group), or 50% lard and 50% FO+LA (M-FO+LA group), or FO+LA (H-FO+LA group). Animals were fed for 10 weeks and then killed for blood collection.
Supplement of FO and LA combination significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the activities of SOD, CAT and GPx as well as the level of GSH, and the significant reduction in lipid peroxidation. Simultaneous intake of FO and LA also reduced plasma TG, TC and LDL-C contents and elevated the ratio of HDL-C/LDL-C. Besides, in parallel with the increase of FO and LA combination, plasma IL-6 and CRP levels were remarkably reduced.
Supplement of FO and LA combination may contribute to prevent atherogenesis by improving plasma oxidative stress, lipid profile and inflammation.
动脉粥样硬化是心血管疾病病理生理学的主要表现。亚麻籽油（FO）和α-硫辛酸（LA）已被报道对心血管系统有潜在益处。本研究试图评估补充 FO 和 LA 混合物对高脂肪饮食喂养大鼠动脉粥样硬化风险因素的影响。
LA 溶解在亚麻籽油中，终浓度为 8 g/kg（FO+LA）。啮齿动物饮食中含有 20%的脂肪。其中五分之一为大豆油，其余为猪油（HFD 组），或 75%猪油和 25%FO+LA（L-FO+LA 组），或 50%猪油和 50%FO+LA（M-FO+LA 组），或 FO+LA（H-FO+LA 组）。动物喂养 10 周后处死取血。
补充 FO 和 LA 混合物显著增强了血浆抗氧化防御能力，表现为 SOD、CAT 和 GPx 活性以及 GSH 水平显著增加，脂质过氧化明显减少。同时摄入 FO 和 LA 还降低了血浆 TG、TC 和 LDL-C 含量，并提高了 HDL-C/LDL-C 比值。此外，随着 FO 和 LA 混合物的增加，血浆 IL-6 和 CRP 水平显著降低。
补充 FO 和 LA 混合物可能通过改善血浆氧化应激、脂质谱和炎症来预防动脉粥样硬化形成。
