Beuth J, Ko H L, Quie P, Pulverer G
Institut für medizinische mikrobiologie und Hygiene der Universität zu Köfn, FR Germany.
Infection. 1990 Jan-Feb;18(1):36-9. doi: 10.1007/BF01644181.
Two strains of Staphylococcus saprophyticus with well characterized cell surface structures were studied to determine the contribution of lectinophagocytosis versus opsonophagocytosis exerted by human phagocytic cells from five healthy donors. The luminol specific chemiluminescence assay was used to evaluate the response of phagocytes. Human polymorphonuclear leukocytes (PMNL) were demonstrated to have surface lectin receptors, since the chemiluminescence response towards both S. saprophyticus strains was inhibited by lectin-specific glycoconjugates for those organisms. Phagocytosis of S. saprophyticus by mononuclear cells was not inhibited by microbial lectin-specific glycoconjugates but was inhibited by D-mannose, suggesting that human monocytes express D-mannose specific lectins on their surface.
对两株具有明确特征的细胞表面结构的腐生葡萄球菌进行了研究，以确定来自五名健康供体的人类吞噬细胞所发挥的凝集素吞噬作用与调理吞噬作用的贡献。使用鲁米诺特异性化学发光测定法来评估吞噬细胞的反应。已证明人类多形核白细胞（PMNL）具有表面凝集素受体，因为针对这两种腐生葡萄球菌菌株的化学发光反应受到针对这些生物体的凝集素特异性糖缀合物的抑制。单核细胞对腐生葡萄球菌的吞噬作用不受微生物凝集素特异性糖缀合物的抑制，但受到D-甘露糖的抑制，这表明人类单核细胞在其表面表达D-甘露糖特异性凝集素。
