Silverblatt F J, Ofek I
Infection. 1983 Jul-Aug;11(4):235-8. doi: 10.1007/BF01641208.
Since Duguid and Guilles first described the ability of piliated bacteria to bind to leukocytes, much has been learned about the nature of this interaction. Mannose-sensitive (MS) pili bind to specific mannose-containing receptors on the leukocyte surface. While MS pili are responsible for attachment, the relative hydrophobicity of the bacterial surface determines whether the organism is internalized. Both binding and ingestion trigger the leukocyte to respond with degranulation and enhanced oxidative activity. The response to piliated bacteria, however, is delayed as compared to bacteria opsonized with serum, which may account for the reduced bactericidal activity associated with pili-mediated phagocytosis. A number of factors appear to influence the significance of pili-mediated phagocytosis in vivo. These include natural selective pressures in the host tissue, the ability of the organism to undergo pili phase transition and the presence of serum or other host opsonic factors. Antipili antibody does not enhance leukocyte killing of MS + Escherichia coli, but does stimulate leukocyte metabolic activity. Antipili antibody may, therefore, have an adverse effect on the infectious process by promoting the extracellular release of inflammatory material from the granulocyte.
自从杜吉德（Duguid）和吉耶尔（Guilles）首次描述了菌毛细菌与白细胞结合的能力以来，人们对这种相互作用的本质已经有了很多了解。甘露糖敏感（MS）菌毛与白细胞表面特定的含甘露糖受体结合。虽然MS菌毛负责附着，但细菌表面的相对疏水性决定了该生物体是否会被内化。结合和摄取都会触发白细胞以脱颗粒和增强氧化活性的方式做出反应。然而，与用血清调理的细菌相比，对菌毛细菌的反应会延迟，这可能解释了与菌毛介导的吞噬作用相关的杀菌活性降低的原因。许多因素似乎会影响菌毛介导的吞噬作用在体内的重要性。这些因素包括宿主组织中的自然选择压力、生物体进行菌毛相变的能力以及血清或其他宿主调理因子的存在。抗菌毛抗体不会增强白细胞对MS + 大肠杆菌的杀伤作用，但会刺激白细胞的代谢活性。因此，抗菌毛抗体可能会通过促进粒细胞释放细胞外炎症物质而对感染过程产生不利影响。
