Engineering Research Centre of Edible and Medicinal Fungi, Ministry of Education, Jilin Agricultural University, Changchun, Jilin 130118, PR China.
J Microbiol Biotechnol. 2012 Nov;22(11):1482-5. doi: 10.4014/jmb.1206.06004.
A natural furan derivative was isolated from the methanolic extract of the fruit bodies of Fomitiporia ellipsoidea. Its chemical structure was elucidated as methyl 3,5-dioxo- 1,3,5,7-tetrahydrobenzo[1,2-c:4,5-c']difuran-4-carboxylate by means of extensive NMR and MS data analysis, and named as fomitiporiaester A (1). Compound 1 showed significant antitumor activity to hepatoma H(22) in vivo, and the inhibition rates were 42.94%, 49.17%, and 58.15% at concentrations of 5, 10, and 20 mg/kg, respectively. Compound 1 showed weak cytotoxic activities against the human hepatoblastoma (HepG-2) and human oophoroma (Skov 3) cell lines with IC(50) values of more than 100 μM.
从椭圆拟层孔菌的甲醇提取物中分离得到一种天然呋喃衍生物。通过广泛的 NMR 和 MS 数据分析，其化学结构被阐明为甲基 3,5-二氧代-1,3,5,7-四氢苯并[1,2-c:4,5-c']二呋喃-4-羧酸酯，并命名为 fomitiporiaester A（1）。化合物 1 在体内对肝癌 H（22）表现出显著的抗肿瘤活性，在 5、10 和 20 mg/kg 浓度下的抑制率分别为 42.94%、49.17%和 58.15%。化合物 1 对人肝癌（HepG-2）和人卵巢癌（Skov 3）细胞系表现出较弱的细胞毒性活性，IC（50）值均大于 100 μM。
