Jinan Pediatric Research Institute, Qilu Children's Hospital of Shandong University, Jinan, 250022, China.
Clin Exp Med. 2014 Feb;14(1):13-24. doi: 10.1007/s10238-012-0218-1. Epub 2012 Nov 3.
Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent stem cells from a variety of tissues with the capability of self-renewal, proliferation, differentiation into multi-lineage cell types, as well as anti-inflammatory and immunomodulatory. These properties make MSCs an ideal source of cell therapy in bone and joint diseases. This review describes the advances of animal study and preliminary clinical application in the past few years, related to MSC-based cell therapy in the common bone and joint diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, osteonecrosis of the femoral head and osteogenesis imperfecta. It highlights the promising prospect of MSC in clinical application of bone and joint diseases.
间充质干细胞（MSCs）是一种非造血祖细胞，来源于多种组织，具有自我更新、增殖、分化为多系细胞类型以及抗炎和免疫调节的能力。这些特性使 MSCs 成为骨与关节疾病细胞治疗的理想来源。本文综述了近年来 MSCs 细胞治疗在常见骨与关节疾病（包括骨关节炎、类风湿关节炎、骨质疏松症、股骨头坏死和成骨不全症）的动物研究和初步临床应用中的进展，突出了 MSCs 在骨与关节疾病临床应用中的广阔前景。
