Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Phys Med Biol. 2012 Dec 7;57(23):7767-81. doi: 10.1088/0031-9155/57/23/7767. Epub 2012 Nov 6.
Plastic scintillation detectors (PSDs) have many advantages over other detectors in small field dosimetry due to their high spatial resolution, excellent water equivalence and instantaneous readout. However, in proton beams, the PSDs undergo a quenching effect which makes the signal level reduced significantly when the detector is close to the Bragg peak where the linear energy transfer (LET) for protons is very high. This study measures the quenching correction factor (QCF) for a PSD in clinical passive-scattering proton beams and investigates the feasibility of using PSDs in depth-dose measurements in proton beams. A polystyrene-based PSD (BCF-12, ϕ0.5 mm × 4 mm) was used to measure the depth-dose curves in a water phantom for monoenergetic unmodulated proton beams of nominal energies 100, 180 and 250 MeV. A Markus plane-parallel ion chamber was also used to get the dose distributions for the same proton beams. From these results, the QCF as a function of depth was derived for these proton beams. Next, the LET depth distributions for these proton beams were calculated by using the MCNPX Monte Carlo code, based on the experimentally validated nozzle models for these passive-scattering proton beams. Then the relationship between the QCF and the proton LET could be derived as an empirical formula. Finally, the obtained empirical formula was applied to the PSD measurements to get the corrected depth-dose curves and they were compared to the ion chamber measurements. A linear relationship between the QCF and LET, i.e. Birks' formula, was obtained for the proton beams studied. The result is in agreement with the literature. The PSD measurements after the quenching corrections agree with ion chamber measurements within 5%. PSDs are good dosimeters for proton beam measurement if the quenching effect is corrected appropriately.
塑料闪烁探测器 (PSD) 在小场剂量学中具有许多优势,因为它们具有高空间分辨率、优异的水等效性和瞬时读取功能。然而,在质子束中,PSD 会经历猝灭效应,当探测器接近质子线性能量转移 (LET) 非常高的布拉格峰时,信号水平会显著降低。本研究测量了临床被动散射质子束中 PSD 的猝灭校正因子 (QCF),并研究了 PSD 在质子束深度剂量测量中的可行性。使用基于聚苯乙烯的 PSD (BCF-12,ϕ0.5mm×4mm) 测量水模体中单能未调制质子束的深度剂量曲线,标称能量为 100、180 和 250 MeV。还使用 Markus 平面平行电离室获得相同质子束的剂量分布。根据这些结果,推导出了这些质子束的 QCF 与深度的函数关系。接下来,根据这些被动散射质子束经过实验验证的喷嘴模型,使用 MCNPX 蒙特卡罗代码计算了这些质子束的 LET 深度分布。然后可以推导出 QCF 与质子 LET 之间的关系作为经验公式。最后,将获得的经验公式应用于 PSD 测量,以获得校正后的深度剂量曲线,并将其与电离室测量进行比较。对于所研究的质子束,QCF 与 LET 之间存在线性关系,即 Birks 公式。这一结果与文献相符。经过猝灭校正后的 PSD 测量值与电离室测量值的误差在 5%以内。如果适当校正猝灭效应,PSD 是质子束测量的良好剂量计。