Department of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Disease, Shanghai, China.
J Dig Dis. 2013 Jan;14(1):11-5. doi: 10.1111/j.1751-2980.2012.00647.x.
Gastric cancer (GC) is one of the most common cancers in the world. The incidence and mortality rate of GC vary among different countries. It is suggested that GC is the result of the interaction between Helicobacter pylori (H. pylori) infection and the genetic and environmental factors in the host. H. pylori infection is the trigger of intestinal gastric adenocarcinoma. The incidence of GC is highest in East Asia and East Europe, but much lower in Africa; however, H. pylori infection is commonly seen in Africa, which is known as the African enigma. The 5-year survival of early GC is far better than that of advanced GC. A high detection rate of early GC could help us to conquer GC. A decreasing trend of GC incidence has been witnessed worldwide. With the improvement of living conditions and the achievements of scientific research, it seems possible that there will be a further reduction in the incidence of GC in the new century.
胃癌（GC）是世界上最常见的癌症之一。GC 的发病率和死亡率在不同国家有所不同。有人认为，GC 是幽门螺杆菌（H. pylori）感染与宿主遗传和环境因素相互作用的结果。H. pylori 感染是引发肠型胃腺癌的原因。GC 的发病率在东亚和东欧最高，但在非洲则低得多；然而，在非洲 H. pylori 感染很常见，这被称为非洲之谜。早期 GC 的 5 年生存率远高于晚期 GC。早期 GC 的高检出率有助于我们攻克 GC。全世界 GC 的发病率呈下降趋势。随着生活条件的改善和科研成果的取得，在新世纪 GC 的发病率有望进一步降低。
