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从加拿大人类患者中分离到的与牲畜相关的 ST398 型耐甲氧西林金黄色葡萄球菌的全基因组序列。

whole-genome sequence of livestock-associated st398 methicillin-resistant staphylococcus aureus Isolated from Humans in Canada.

机构信息

National Microbiology Laboratory, Winnipeg, Manitoba, Canada.

出版信息

J Bacteriol. 2012 Dec;194(23):6627-8. doi: 10.1128/JB.01680-12.

Abstract

Despite reports of high colonization rates of ST398 livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) among pigs and pig farmers, the incidence of LA-MRSA infection in the general population in Canada appears to be rare in comparison to that in some European countries. In this study, the complete genome sequence of a Canadian representative LA-MRSA isolate (08BA02176) from a human postoperative surgical site infection was acquired and compared to the sequenced genome of an LA-MRSA isolate (S0385) from Europe to identify genetic traits that may explain differences in the success of these particular strains in some locales.

摘要

尽管有报道称 ST398 型与牲畜相关的耐甲氧西林金黄色葡萄球菌(LA-MRSA)在猪和养猪户中的定植率很高,但与一些欧洲国家相比,加拿大普通人群中 LA-MRSA 感染的发病率似乎较低。在这项研究中,从人类术后手术部位感染中获得了一株加拿大代表性 LA-MRSA 分离株(08BA02176)的完整基因组序列,并与来自欧洲的 LA-MRSA 分离株(S0385)的测序基因组进行了比较,以确定可能解释这些特定菌株在某些地区成功的遗传特征。

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