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本文引用的文献

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Induction of virulence gene expression in Staphylococcus aureus by pulmonary surfactant.肺表面活性剂诱导金黄色葡萄球菌毒力基因表达。
Infect Immun. 2014 Apr;82(4):1500-10. doi: 10.1128/IAI.01635-13. Epub 2014 Jan 22.
2
Panton-Valentine leukocidin (PVL) gene carriage among Staphylococcus aureus strains with SCCmec types I, III, IV, and V recovered from cystic fibrosis pediatric patients in Brazil.从巴西囊性纤维化儿科患者中分离出的携带 SCCmec 类型 I、III、IV 和 V 的金黄色葡萄球菌菌株中 Panton-Valentine 白细胞毒素 (PVL) 基因的携带情况。
Diagn Microbiol Infect Dis. 2014 Jan;78(1):59-62. doi: 10.1016/j.diagmicrobio.2013.10.004. Epub 2013 Oct 14.
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Staphylococcus aureus CC398 clade associated with human-to-human transmission.金黄色葡萄球菌 CC398 进化枝与人际传播相关。
Appl Environ Microbiol. 2012 Dec;78(24):8845-8. doi: 10.1128/AEM.02398-12. Epub 2012 Oct 5.
4
SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing.SPAdes：一种新的基因组组装算法及其在单细胞测序中的应用
J Comput Biol. 2012 May;19(5):455-77. doi: 10.1089/cmb.2012.0021. Epub 2012 Apr 16.
5
Molecular epidemiology of meticillin-resistant Staphylococcus aureus in Italian cystic fibrosis patients: a national overview.耐甲氧西林金黄色葡萄球菌的分子流行病学在意大利囊性纤维化患者：国家概述。
J Cyst Fibros. 2011 Dec;10(6):407-11. doi: 10.1016/j.jcf.2011.06.005. Epub 2011 Jul 12.
6
Whole genome analysis of a livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolate from a case of human endocarditis.从一例人类心内膜炎病例中分离出的一株与家畜相关的耐甲氧西林金黄色葡萄球菌 ST398 的全基因组分析。
BMC Genomics. 2010 Jun 14;11:376. doi: 10.1186/1471-2164-11-376.
7
Occurrence and genotyping using automated repetitive-sequence-based PCR of methicillin-resistant Staphylococcus aureus ST398 in Southeast Austria.在奥地利东南部，利用基于自动化重复序列的 PCR 对耐甲氧西林金黄色葡萄球菌 ST398 的发生和基因分型。
Diagn Microbiol Infect Dis. 2010 Feb;66(2):217-21. doi: 10.1016/j.diagmicrobio.2009.09.006. Epub 2009 Oct 13.
8
Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance.ArdA抗限制蛋白的广泛DNA模拟及其在抗生素耐药性传播中的作用。
Nucleic Acids Res. 2009 Aug;37(15):4887-97. doi: 10.1093/nar/gkp478. Epub 2009 Jun 8.
9
High prevalence in cystic fibrosis patients of multiresistant hospital-acquired methicillin-resistant Staphylococcus aureus ST228-SCCmecI capable of biofilm formation.囊性纤维化患者中具有生物膜形成能力的多重耐药医院获得性耐甲氧西林金黄色葡萄球菌ST228-SCCmecI的高流行率。
J Antimicrob Chemother. 2008 Nov;62(5):961-7. doi: 10.1093/jac/dkn302. Epub 2008 Jul 21.
10
Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans.猪和人类中的耐甲氧西林和甲氧西林敏感金黄色葡萄球菌序列型398
Emerg Infect Dis. 2008 Mar;14(3):479-83. doi: 10.3201/eid1403.070760.

从一名患有囊性纤维化的巴西患者身上分离出的耐多药家畜相关耐甲氧西林金黄色葡萄球菌ST398的基因组信息。

Genomic information on multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST398 isolated from a Brazilian patient with cystic fibrosis.

作者信息

Lima Danielle F, Cohen Renata Wf, Rocha Géssica A, Albano Rodolpho M, Marques Elizabeth A, Leão Robson S

机构信息

Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Microbiologia, Imunologia e Parasitologia, Rio de Janeiro, RJ, Brasil.

Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Rio de Janeiro, RJ, Brasil.

出版信息

Mem Inst Oswaldo Cruz. 2017 Jan 1;112(1):79-80. doi: 10.1590/0074-02760160342.

DOI:10.1590/0074-02760160342
PMID:28076471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5225532/
Abstract

Alarmingly, the isolation of methicillin-resistant Staphylococcus aureus (MRSA) has been increasing among patients with cystic fibrosis (CF). During a previous molecular characterisation of MRSA isolates obtained from patients with CF from Rio de Janeiro, Brazil, one isolate was identified as the ST398 clone, a livestock-associated (LA) MRSA. In this study, we report the draft genome sequence of an LA-MRSA ST398 clone isolated from a patient with CF.

摘要

令人担忧的是，耐甲氧西林金黄色葡萄球菌（MRSA）在囊性纤维化（CF）患者中的分离率一直在上升。在之前对从巴西里约热内卢的CF患者中分离出的MRSA菌株进行分子特征分析时，有一株菌株被鉴定为ST398克隆，这是一种与牲畜相关的（LA）MRSA。在本研究中，我们报告了从一名CF患者中分离出的LA-MRSA ST398克隆的基因组草图序列。