将供体/受体卡宾扩展到 N-邻苯二甲酰亚胺供体基团：1-环丙烷 α-氨基酸的非对映选择性合成。
Expanding the scope of donor/acceptor carbenes to N-phthalimido donor groups: diastereoselective synthesis of 1-cyclopropane α-amino acids.
机构信息
Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
出版信息
Org Lett. 2012 Dec 7;14(23):6020-3. doi: 10.1021/ol3029127. Epub 2012 Nov 15.
PMID:23153274
Abstract
Warming of 4-phthalimido-N-mesyl-1,2,3-triazole in the presence of alkenes followed by silica gel induced hydrolysis results in a highly diastereoselective and catalyst-free entry to N-phthalimidocyclopropanecarboxaldehydes.
摘要
4-邻苯二甲酰亚氨基-N-甲磺酰基-1,2,3-三唑在烯烃存在下进行加热，随后进行硅胶诱导水解，可得到高度非对映选择性且无催化剂的 N-邻苯二甲酰亚氨基环丙甲酰醛。
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