The Wilmer Eye Institute, Baltimore, MD, USA.
Cell Adh Migr. 2013 Jan-Feb;7(1):82-9. doi: 10.4161/cam.22480. Epub 2012 Nov 15.
The mechanisms controlling vascular development, both normal and pathological, are not yet fully understood. Many diseases, including cancer and diabetic retinopathy, involve abnormal blood vessel formation. Therefore, increasing knowledge of these mechanisms may help develop novel therapeutic targets. The identification of novel proteins or cells involved in this process would be particularly useful. The retina is an ideal model for studying vascular development because it is easy to access, particularly in rodents where this process occurs post-natally. Recent studies have suggested potential roles for laminin chains in vascular development of the retina. This review will provide an overview of these studies, demonstrating the importance of further research into the involvement of laminins in retinal blood vessel formation.
控制血管发育的机制，无论是正常的还是病理性的，尚未完全被理解。许多疾病，包括癌症和糖尿病性视网膜病变，都涉及异常血管形成。因此，增加对这些机制的了解可能有助于开发新的治疗靶点。鉴定参与这一过程的新蛋白或细胞将特别有用。视网膜是研究血管发育的理想模型，因为它很容易被获取，特别是在这个过程发生在出生后的啮齿动物中。最近的研究表明，层粘连蛋白链在视网膜血管发育中可能具有潜在作用。本综述将提供这些研究的概述，展示进一步研究层粘连蛋白在视网膜血管形成中的作用的重要性。
