Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PLoS One. 2012;7(11):e48735. doi: 10.1371/journal.pone.0048735. Epub 2012 Nov 14.
The interaction of the association of dopamine genes, impulsivity and childhood trauma with substance abuse remains unclear.
To clarify the impacts and the interactions of the Catechol -O-methyltransferase (COMT) gene, impulsivity and childhood trauma on the age of onset of heroin use among heroin dependent patients in China.
202 male and 248 female inpatients who meet DSM-IV criteria of heroin dependence were enrolled. Impulsivity and childhood trauma were measured using BIS-11 (Barratt Impulsiveness Scale-11) and ETISR-SF (Early Trauma Inventory Self Report-Short Form). The single nucleotide polymorphism (SNP) rs737866 on the COMT gene-which has previously been associated with heroin abuse, was genotyped using a DNA sequence detection system. Structural equations model was used to assess the interaction paths between these factors and the age of onset of heroin use.
Chi-square test indicated the individuals with TT allele have earlier age of onset of heroin use than those with CT or CC allele. In the correlation analysis, the severity of childhood trauma was positively correlated to impulsive score, but both of them were negatively related to the age of onset of heroin use. In structure equation model, both the COMT gene and childhood trauma had impacts on the age of onset of heroin use directly or via impulsive personality.
Our findings indicated that the COMT gene, impulsive personality traits and childhood trauma experience were interacted to impact the age of onset of heroin use, which play a critical role in the development of heroin dependence. The impact of environmental factor was greater than the COMT gene in the development of heroin dependence.
多巴胺基因、冲动和儿童创伤与物质滥用之间的相互作用仍不清楚。
阐明儿茶酚-O-甲基转移酶（COMT）基因、冲动和儿童创伤对中国海洛因依赖患者海洛因使用起始年龄的影响及其相互作用。
纳入 202 名男性和 248 名符合 DSM-IV 海洛因依赖标准的女性住院患者。使用 BIS-11（巴瑞特冲动量表-11）和 ETISR-SF（早期创伤清单自我报告-简短形式）测量冲动和儿童创伤。使用 DNA 序列检测系统对 COMT 基因上的单核苷酸多态性（SNP）rs737866 进行基因分型，该 SNP 先前与海洛因滥用相关。采用结构方程模型评估这些因素与海洛因使用起始年龄之间的相互作用路径。
卡方检验表明，TT 等位基因个体的海洛因使用起始年龄早于 CT 或 CC 等位基因个体。在相关性分析中，儿童创伤的严重程度与冲动得分呈正相关，但两者均与海洛因使用起始年龄呈负相关。在结构方程模型中，COMT 基因和儿童创伤均直接或通过冲动个性对海洛因使用起始年龄产生影响。
我们的研究结果表明，COMT 基因、冲动个性特征和儿童创伤经历相互作用，影响海洛因使用起始年龄，在海洛因依赖的发展中起着关键作用。在海洛因依赖的发展中，环境因素的影响大于 COMT 基因。
