多囊卵巢综合征中促性腺激素释放激素长效激动剂与灵活促性腺激素释放激素拮抗剂方案的前瞻性研究：印度经验
A prospective study of GnRH long agonist versus flexible GnRH antagonist protocol in PCOS: Indian experience.
作者信息
Kaur Harpreet, Krishna Deepika, Shetty Nivedita, Krishnan Sandhya, Srinivas Ms, Rao Kamini Arvind
机构信息
Department of Reproductive Medicine Medicine Unit, Bangalore Assisted Conception Centre, Bangalore, India.
出版信息
J Hum Reprod Sci. 2012 May;5(2):181-6. doi: 10.4103/0974-1208.101017.
BACKGROUND
Polycystic ovarian syndrome is a common endocrine disorder of reproductive age women. Many controlled ovarian stimulation (COS) strategies have been offered for the treatment of patients with PCOS undergoing in vitro fertilization, but the optimal protocol is still a controversy. There is no compelling evidence for the advantage of one stimulation protocol over the other.
MATERIALS AND METHODS
This is a single-center prospective controlled study comparing long agonist and antagonist protocol in PCOS women.
RESULTS
There was no significant difference in live birth rate and clinical pregnancy rate. Rate of ovarian hyperstimulation syndrome was significantly higher in the agonist group. Number of oocytes retrieved, number of follicles and peak estradiol levels were significantly more in the agonist group.
CONCLUSION
The GnRH antagonist protocol is an equally effective but safer protocol in PCOS patients compared with the long agonist protocol.
背景
多囊卵巢综合征是育龄期女性常见的内分泌紊乱疾病。对于接受体外受精的多囊卵巢综合征患者，已经有多种控制性卵巢刺激（COS）策略用于治疗，但最佳方案仍存在争议。没有令人信服的证据表明一种刺激方案比另一种更具优势。
材料与方法
这是一项单中心前瞻性对照研究，比较多囊卵巢综合征女性的长效激动剂方案和拮抗剂方案。
结果
活产率和临床妊娠率无显著差异。激动剂组卵巢过度刺激综合征的发生率显著更高。激动剂组获取的卵母细胞数量、卵泡数量和雌二醇峰值水平显著更多。
结论
与长效激动剂方案相比，GnRH拮抗剂方案在多囊卵巢综合征患者中同样有效但更安全。
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