软珊瑚 Sarcophyton elegans 中的新海兔烷类化合物 Sarcophyolides B-E。
Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
出版信息
Mar Drugs. 2013 Aug 26;11(9):3186-96. doi: 10.3390/md11093186.
Abstract
Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocrasol were found to exhibit potent inhibition against A2780 human ovarian tumor cells.
摘要
从软珊瑚 Sarcophyton elegans 中分离得到了四个新的海鞘烷型二萜类化合物 sarcophyolide B-E（1-4）以及 11 个已知类似物。新化合物 1-4 的结构是基于光谱分析和化学转化确定的。新的海鞘烷类化合物 sarcophyolide B（1）和 lobocrasol 被发现对 A2780 人卵巢肿瘤细胞具有很强的抑制作用。
Zotero 插件