病毒感染中的中性粒细胞：是敌是友？
Neutrophil in viral infections, friend or foe?
机构信息
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA.
出版信息
Virus Res. 2013 Jan;171(1):1-7. doi: 10.1016/j.virusres.2012.11.002. Epub 2012 Nov 21.
Abstract
Polymorphonuclear leukocytes or neutrophils are the first immune cells to the site of injury and microbial infection. Neutrophils are crucial players in controlling bacterial and fungal infections, and in particular secondary infections, by phagocytosis, degranulation and neutrophil extracellular traps (NETs). While neutrophils have been shown to play important roles in viral pathogenesis, there is a lack of detailed investigation. In this article, we will review recent progresses toward understanding the role of neutrophils in viral pathogenesis.
摘要
多形核白细胞或中性粒细胞是第一个到达损伤和微生物感染部位的免疫细胞。中性粒细胞在吞噬、脱颗粒和中性粒细胞细胞外陷阱（NETs）方面对抗细菌和真菌感染，特别是继发感染，起着至关重要的作用。虽然已经证明中性粒细胞在病毒发病机制中起重要作用，但缺乏详细的研究。在本文中，我们将回顾理解中性粒细胞在病毒发病机制中的作用的最新进展。
相似文献
1
Neutrophil in viral infections, friend or foe?病毒感染中的中性粒细胞：是敌是友？
Virus Res. 2013 Jan;171(1):1-7. doi: 10.1016/j.virusres.2012.11.002. Epub 2012 Nov 21.
2
Neutrophils in viral infection.病毒感染中的中性粒细胞。
Cell Tissue Res. 2018 Mar;371(3):505-516. doi: 10.1007/s00441-017-2763-0. Epub 2018 Jan 11.
3
Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.了解中性粒细胞胞外诱捕网（NETs）的分子机制及其在抗病毒天然免疫中的作用。
Virus Res. 2017 Jan 15;228:124-133. doi: 10.1016/j.virusres.2016.11.033. Epub 2016 Dec 5.
4
Natural Variation in Clinical Isolates of Candida albicans Modulates Neutrophil Responses.白色念珠菌临床分离株的自然变异调节中性粒细胞反应。
mSphere. 2020 Aug 19;5(4):e00501-20. doi: 10.1128/mSphere.00501-20.
5
Neutrophils: neglected players in viral diseases.中性粒细胞：病毒疾病中被忽视的角色。
DNA Cell Biol. 2013 Dec;32(12):665-75. doi: 10.1089/dna.2013.2211. Epub 2013 Nov 15.
6
Pathogenic and Protective Roles of Neutrophils in Infection.中性粒细胞在感染中的致病及保护作用
Pathogens. 2025 Jan 23;14(2):112. doi: 10.3390/pathogens14020112.
7
The role of phagocytosis, oxidative burst and neutrophil extracellular traps in the interaction between neutrophils and the periodontal pathogen Porphyromonas gingivalis.吞噬作用、氧化爆发和中性粒细胞胞外陷阱在中性粒细胞与牙周病原体牙龈卟啉单胞菌相互作用中的作用。
Mol Oral Microbiol. 2015 Oct;30(5):361-75. doi: 10.1111/omi.12099. Epub 2015 May 4.
8
Neutrophil subset responses in infants with severe viral respiratory infection.患有严重病毒性呼吸道感染的婴儿中性粒细胞亚群反应
Clin Immunol. 2017 Mar;176:100-106. doi: 10.1016/j.clim.2016.12.012. Epub 2017 Jan 17.
9
Neutrophil extracellular traps as a new paradigm in innate immunity: friend or foe?中性粒细胞胞外陷阱作为固有免疫的新模式：是敌是友？
Periodontol 2000. 2013 Oct;63(1):165-97. doi: 10.1111/prd.12025.
10
Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps.中性粒细胞被招募到感染部位，通过释放中性粒细胞胞外陷阱来抵御病毒的挑战。
Cell Host Microbe. 2013 Feb 13;13(2):169-80. doi: 10.1016/j.chom.2013.01.005.
引用本文的文献
1
Neurological manifestations of encephalitic alphaviruses, traumatic brain injuries, and organophosphorus nerve agent exposure.脑炎型甲病毒、创伤性脑损伤和有机磷神经毒剂暴露的神经学表现。
Front Neurosci. 2024 Dec 13;18:1514940. doi: 10.3389/fnins.2024.1514940. eCollection 2024.
2
Recent Advances in Immunological Landscape and Immunotherapeutic Agent of Nipah Virus Infection.尼帕病毒感染的免疫景观和免疫治疗剂的最新进展。
Cell Biochem Biophys. 2024 Dec;82(4):3053-3069. doi: 10.1007/s12013-024-01424-4. Epub 2024 Jul 25.
3
Measures of Oxidative Status Markers in Relation to Age, Sex, and Season in Sick and Healthy Captive Asian Elephants in Thailand.泰国圈养的患病和健康亚洲象体内氧化状态标志物与年龄、性别和季节的关系
Animals (Basel). 2023 May 5;13(9):1548. doi: 10.3390/ani13091548.
4
COVID-19 Pathology Sheds Further Light on Balance between Neutrophil Proteases and Their Inhibitors.COVID-19 病理学进一步揭示了中性粒细胞蛋白酶与其抑制剂之间的平衡。
Biomolecules. 2022 Dec 30;13(1):82. doi: 10.3390/biom13010082.
5
Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes.重复给药通过与血管内单核细胞相互作用改善溶瘤弹状病毒治疗在小鼠中的效果。
Commun Biol. 2022 Dec 19;5(1):1385. doi: 10.1038/s42003-022-04254-3.
6
Neutrophil Extracellular Traps in Asthma: Friends or Foes?中性粒细胞胞外诱捕网在哮喘中的作用：是敌是友？
Cells. 2022 Nov 7;11(21):3521. doi: 10.3390/cells11213521.
7
The Immunobiology of Nipah Virus.尼帕病毒的免疫生物学
Microorganisms. 2022 Jun 6;10(6):1162. doi: 10.3390/microorganisms10061162.
8
Neutrophils in COVID-19: Not Innocent Bystanders.新型冠状病毒肺炎中的中性粒细胞：并非无辜旁观者。
Front Immunol. 2022 Jun 1;13:864387. doi: 10.3389/fimmu.2022.864387. eCollection 2022.
9
Impairment of neutrophil functions and homeostasis in COVID-19 patients: association with disease severity.COVID-19 患者中性粒细胞功能和稳态受损：与疾病严重程度的关联。
Crit Care. 2022 May 30;26(1):155. doi: 10.1186/s13054-022-04002-3.
10
Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model.对严重发热伴血小板减少综合征病毒感染所引发免疫反应的探索揭示，在免疫受损小鼠模型中，白细胞介素-6是一个治疗靶点。
PNAS Nexus. 2022 Mar 10;1(1):pgac024. doi: 10.1093/pnasnexus/pgac024. eCollection 2022 Mar.
本文引用的文献
1
Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells.感染肺部中的流感感染中性粒细胞作为抗病毒 CD8(+) T 细胞的抗原呈递细胞。
PLoS One. 2012;7(10):e46581. doi: 10.1371/journal.pone.0046581. Epub 2012 Oct 8.
2
Neutrophil extracellular traps: is immunity the second function of chromatin?中性粒细胞胞外陷阱：染色质的第二种功能是免疫吗？
J Cell Biol. 2012 Sep 3;198(5):773-83. doi: 10.1083/jcb.201203170.
3
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.中性粒细胞胞外诱捕网介导宿主对人类免疫缺陷病毒-1 的防御反应。
Cell Host Microbe. 2012 Jul 19;12(1):109-16. doi: 10.1016/j.chom.2012.05.015.
4
ETosis: A Microbicidal Mechanism beyond Cell Death.胞外诱捕网形成：一种超越细胞死亡的杀菌机制。
J Parasitol Res. 2012;2012:929743. doi: 10.1155/2012/929743. Epub 2012 Feb 26.
5
Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouse.肝和脑中的趋化和炎症反应与裂谷热病毒感染在小鼠中的发病机制相关。
PLoS Negl Trop Dis. 2012;6(2):e1529. doi: 10.1371/journal.pntd.0001529. Epub 2012 Feb 28.
6
Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host.天然鼠宿主中遗传修饰的小核糖核酸病毒引起的下呼吸道感染。
PLoS One. 2012;7(2):e32061. doi: 10.1371/journal.pone.0032061. Epub 2012 Feb 15.
7
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection.TLR2/MyD88/NF-κB 通路、活性氧、钾离子外流在呼吸道合胞病毒感染过程中激活 NLRP3/ASC 炎症小体。
PLoS One. 2012;7(1):e29695. doi: 10.1371/journal.pone.0029695. Epub 2012 Jan 25.
8
Towards a four-dimensional view of neutrophils.迈向中性粒细胞的四维视角。
Methods Mol Biol. 2012;844:87-99. doi: 10.1007/978-1-61779-527-5_6.
9
An oligodeoxynucleotide capable of lessening acute lung inflammatory injury in mice infected by influenza virus.一种寡脱氧核苷酸，可减轻流感病毒感染小鼠的急性肺炎症损伤。
Biochem Biophys Res Commun. 2011 Nov 18;415(2):342-7. doi: 10.1016/j.bbrc.2011.10.062. Epub 2011 Oct 18.
10
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6.单纯疱疹病毒感染诱导活性氧的产生，从而增强模式识别受体的信号转导：TRAF3 和 6 的 S-谷胱甘肽化的作用。
PLoS Pathog. 2011 Sep;7(9):e1002250. doi: 10.1371/journal.ppat.1002250. Epub 2011 Sep 15.
Zotero 插件