Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Clin Oncol (R Coll Radiol). 2013 Feb;25(2):127-34. doi: 10.1016/j.clon.2012.10.013. Epub 2012 Nov 22.
A 3 week schedule of whole breast radiotherapy is firmly established in the UK and is becoming more accepted internationally, especially as accelerated partial breast radiotherapy regimens become more common. It seems that a 3 week schedule is unlikely to be the lower limit of whole breast hypofractionation and the partial breast may even be adequately treated with just a single treatment. It is, however, essential that these hypotheses are rigorously tested within well-designed trials to ensure the highest quality of radiotherapy. This overview will address the rationale for hypofractionation in breast cancer, discuss past trials and outline the design of current studies.
在英国，为期 3 周的全乳腺放射治疗方案已经得到了牢固确立，并且在国际上也越来越被接受，尤其是随着加速部分乳腺放射治疗方案变得越来越普遍。似乎 3 周的时间表不太可能成为全乳腺分割放疗的下限，部分乳腺甚至只用一次治疗就可以得到充分治疗。然而，至关重要的是，这些假设必须在精心设计的试验中得到严格检验，以确保放射治疗的最高质量。本综述将讨论乳腺癌分割放疗的基本原理，讨论过去的试验，并概述当前研究的设计。
